33 citations
,
November 2008 in “European Journal of Pharmaceutical Sciences” This study found that St. John's wort treatment for two weeks induced finasteride metabolism and reduced its plasma exposure in healthy men.
33 citations
,
August 1973 in “American Heart Journal” Propranolol can cause reversible hair loss.
30 citations
,
March 2015 in “Clinical Endocrinology” This study found that late adolescent and young women with clinical hyperandrogenism, including PCOS, experienced higher psychological distress and impaired well-being compared to their healthy peers.
29 citations
,
January 2006 in “Clinical chemistry and laboratory medicine” This study found that male liver cirrhosis patients have higher estradiol levels and lower dehydroepiandrosterone sulfate, leading to hormonal imbalances favoring estradiol, but without changing sex hormone-binding globulin's binding properties.
29 citations
,
October 1988 in “Journal of Steroid Biochemistry” This review discusses the use of antiandrogens for various conditions like prostate cancer and highlights their potential benefits in remission rates and symptom improvement, but it reports no new clinical results.
28 citations
,
January 2003 in “Skin pharmacology and physiology” This study found that melatonin's effect on HaCaT keratinocyte proliferation varied with concentration and incubation time, with no cytotoxic effects observed at suitable concentrations for skin treatment.
27 citations
,
April 1996 in “Baillière's clinical endocrinology and metabolism” This article discusses the diagnostic complexities of PCOS and emphasizes the importance of differentiating between polycystic ovaries and polycystic ovary syndrome; it presents no new experimental results.
26 citations
,
June 2010 in “Acta Pharmaceutica” The researchers reported that they successfully developed and validated RP-HPLC and TLC methods for accurately measuring tamsulosin hydrochloride and finasteride in combination forms.
26 citations
,
April 2009 in “Australasian Journal of Dermatology” In this study, a 9-year-old girl with female pattern hair loss showed clinical improvement and hair regrowth after six months of daily oral spironolactone.
26 citations
,
January 1992 in “Cancer investigation” This study found that N-acetylcysteine effectively prevented cyclophosphamide-induced alopecia in rats, and ImuVert plus N-acetylcysteine prevented alopecia from a cyclophosphamide-cytarabine combination.
25 citations
,
February 2012 in “The Journal of Sexual Medicine” In this study, oral finasteride treatment for four weeks reduced the weight of the corpus cavernosum in rats but did not significantly affect erectile function.
25 citations
,
February 1989 in “The Journal of Clinical Pharmacology” This document studied minoxidil in healthy volunteers. Minoxidil is quickly absorbed and eliminated from the body.
24 citations
,
June 2011 in “International Journal of Dermatology” This review summarizes physiologic skin changes during pregnancy and specific pregnancy-related dermatoses but reports no new clinical results.
24 citations
,
May 2010 in “Hautarzt” This review explores various hormone influences on hair growth and loss beyond androgens, noting that clinical hormone therapies for aging may impact hair due to associated hormone level reductions, but reports no new empirical results.
22 citations
,
October 2018 in “Aesthetic Plastic Surgery” This review discusses the latest understanding of androgenetic alopecia, including stem cell niches in hair follicles, and highlights emerging treatments like growth factors and platelet-rich plasma without new clinical findings.
22 citations
,
December 2016 in “PloS one” In this study, researchers found that the EDMTFH protein is present in specific layers of the chicken embryo skin and feathers, suggesting its role in feather mechanics and development.
22 citations
,
October 2012 in “Cell Transplantation” This study found that adding Wnt-10b to the culture medium of dermal papilla cells maintained their ability to induce hair follicles over 100 days in vitro.
22 citations
,
February 2008 in “Journal of Neurochemistry” This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.
22 citations
,
January 2006 in “International Journal of Andrology” This study found that coadministration of 5α-reductase inhibitors with oral testosterone in oil significantly increases serum testosterone levels in medically castrated men compared to testosterone alone, with food intake minimally affecting these levels.
21 citations
,
January 2013 in “Annals of dermatology/Annals of Dermatology” In this study, combination therapy with cyclosporine and PUVA for severe alopecia areata resulted in a majority of patients showing only fair to poor responses, though some improvements were noted.
20 citations
,
July 2006 in “Veterinary dermatology” This study found that hair regrowth in Pomeranians with hair cycle arrest treated with melatonin was not associated with a change in oestrogen receptor-α staining.
20 citations
,
October 2003 in “The Journal of Dermatology” This study observed that while dexamethasone-cyclophosphamide pulse therapy is relatively free from hypertension and diabetes compared to conventional steroids in pemphigus patients, it frequently causes generalized weakness and flushing.
19 citations
,
October 2020 in “Journal der Deutschen Dermatologischen Gesellschaft” This review found that despite varied levels of stigmatization reported in studies, hair loss generally leads to stigmatization and a reduced quality of life, but specific research on this stigma is limited.
19 citations
,
March 2017 in “PLoS ONE” This study found that intact pilosebaceous units were more effective than truncated hair follicles at regenerating a multilayered epidermis in a de-epidermalized dermis in vitro.
19 citations
,
August 2010 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses plant extracts for dermatological use, highlighting evidence that some can reduce edema in chronic venous insufficiency or help treat actinic keratoses, but it reports no new clinical results.
18 citations
,
January 2014 in “Postępy Dermatologii i Alergologii” This paper reviews current treatments for alopecia areata and emphasizes the importance of tailoring therapy to each patient's specific condition and needs without reporting new clinical results.
18 citations
,
January 2003 in “Gynecological Endocrinology” In this study, low-dose finasteride (2.5 mg/day) significantly reduced hirsutism scores in women over 12 months without significant hormonal changes or serious side effects.
17 citations
,
September 2020 in “Journal of Endocrinological Investigation” This study found that the gut microbiota composition in patients with post-finasteride syndrome differs significantly from healthy controls, with reduced diversity and specific microbial changes, suggesting a potential diagnostic marker and therapeutic target.
17 citations
,
September 2013 in “The International Journal of Neuropsychopharmacology” This study found that neonatal finasteride treatment in male rats altered hippocampal GABAA receptor subunit expression and led to increased anxiety-like behavior in response to progesterone in adulthood.
17 citations
,
February 2001 in “Urologia Internationalis” This study found that patients with bladder outlet obstruction and moderately enlarged prostates are likely to successfully discontinue the a-blocker doxazosin after 9 months of combination therapy with finasteride.