June 2020 in “Journal of Investigative Dermatology” This study found that FDA-cleared devices for preparing platelet-rich plasma showed inconsistent product quality, with variable platelet counts and inadequate quality control performance, suggesting clinical improvement may not rely on platelet concentration.
This study found that blood cell count derived parameters were similar across non-cicatricial alopecia groups but showed general differences when compared to psoriasis and hidradenitis suppurativa. Among patients with alopecia areata, modulating platelet number and volume may serve as a therapeutic marker.
4 citations
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December 2016 in “Blood” This study describes a case of cyclic thrombocytopenia where a novel MPL gene mutation may contribute to the disease, with gene expression changes in platelet and neutrophil genes preceding platelet count fluctuations.
September 2024 in “Cureus” In this study, researchers optimized a method for preparing platelet-rich plasma to improve light transmittance aggregometry testing in coronary artery disease patients on clopidogrel and ticagrelor, finding distinct differences in platelet aggregation and volumes among these patients compared to healthy controls.
4 citations
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August 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study developed the iCOUNT tool, which provides insights into stem cell behavior by tracking cell division events and molecular consequences in human and mouse neural stem/progenitor cells.
January 2021 in “Research Square (Research Square)” This study found that repeated plateletpheresis had no significant effect on whole blood cells and plasma proteins in donors, maintaining levels within a normal range.
1 citations
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November 2024 in “Bone Reports” This study found that while MSC concentration in BMCs correlates with total cell counts, cellularity does not indicate high MSC content.
59 citations
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October 1976 in “BMJ” This case report observed that a child developed thrombocytopenia, characterized by a low platelet count and prolonged bleeding time, while on sodium valproate monotherapy for seizures.
14 citations
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April 2019 in “The Ukrainian Biochemical Journal” This study developed a simple method to prepare highly concentrated, resting platelet-rich plasma suitable for cell therapy, effectively preventing clotting while maintaining platelet reactivity and minimizing hemorrhage risk.
August 2024 in “OBM Transplantation” This article reviews the use of platelet concentrates in regenerative medicine and highlights the need for standardized protocols and more specific clinical studies, without reporting new clinical results.
March 2024 in “INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH” This study found that platelet-rich plasma therapy may effectively improve hair density and related parameters in men with androgenetic alopecia, with results differing based on specific platelet counts.
September 2024 in “IP Indian Journal of Clinical and Experimental Dermatology” This study found that a centrifugation protocol of 1300 rpm/246 g for 20 minutes followed by 1600 rpm/373 g for 20 minutes achieved the highest platelet yield in platelet-rich plasma.
May 2023 in “Asian Journal of Transfusion Science” In this study, conducted at a tertiary care hospital in Chennai, adverse events during blood donation were observed in 0.42% of donors, predominantly affecting first-time male donors, and were mostly vasovagal reactions such as giddiness and sweating.
April 2024 in “Lečaŝij vrač” This study found that thrombocytopenia is a common side effect of valproic acid, affecting up to 54% of elderly patients, but it is under-investigated despite significant therapeutic consequences.
6 citations
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January 2014 in “American Journal of Medical Case Reports” This case report highlights a 17-year-old girl with overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus, emphasizing the critical importance of early diagnosis and intensive therapy including plasma exchange.
July 2023 in “Research Square (Research Square)” In this study conducted on rabbits, conventional blood treated with 120% sodium citrate was observed to achieve the highest platelet recovery and enrichment coefficient, while altering sodium citrate concentrate affected levels of growth factors PDGF and TGF-β1 after plasma activation.
August 2018 in “Journal of The American Academy of Dermatology” Patients with multiple superficial venous thrombosis are at greater risk for serious complications like cancer and recurrent blood clots.
Low vitamin C caused bleeding and corkscrew hair, resolved with vitamin C treatment.
20 citations
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August 2020 in “Stem Cell Research & Therapy” This study found that miR-150 enhances the resolution ability of endothelial progenitor cells in venous thrombosis by promoting cell differentiation and proliferation through specific gene regulation pathways.
10 citations
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May 2011 in “American Journal of Hematology” This study found that vinblastine treatment rapidly increased platelet counts in childhood refractory immune thrombocytopenia, providing effective control of bleeding symptoms, although side effects like neuropathic pain were common and resolved with dose adjustments.
July 2023 in “Dermatology and therapy” In patients with alopecia areata, this study found elevated levels of venous thromboembolism markers SFMC and F1 + 2 compared to healthy controls, potentially indicating an increased risk for this condition.
29 citations
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January 2009 in “Gynecological Endocrinology” This study found that women with polycystic ovary syndrome have significantly higher plasma levels of thrombin-activatable fibrinolysis inhibitor and other hemostatic markers compared to age- and BMI-matched healthy controls.
1 citations
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September 2021 in “Biomedical & Pharmacology Journal” This study found that the reticulocyte hemoglobin content (CHr) most frequently indicated iron deficiency in female patients with diffuse non-scarring hair loss.
This study found that a short-term treatment with all-trans retinoic acid may effectively stabilize platelet counts in idiopathic thrombocytopenic purpura patients experiencing fluctuations during thrombopoietin receptor agonist therapy.
13 citations
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July 1996 in “Annals of Internal Medicine” In this letter, thrombocytosis was associated with the use of low-molecular-weight heparin in a patient with adrenal cortical carcinoma, highlighting a potential side effect of this treatment.
11 citations
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March 2024 in “Cell and Tissue Research” In this review, researchers summarize the methods for characterizing telocytes, outline their physiological roles and implications in diseases, and discuss potential future studies including precise markers and targeted therapies.
1 citations
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January 2003 in “The Pediatric Infectious Disease Journal” This case report describes a 13-year-old boy with febrile illness and hair loss who was diagnosed with an unspecified condition after worsening symptoms on Hospital Day 10, following initial recovery.
November 2023 in “Gastroenterology” This case study identified non-criteria antiphospholipid syndrome as a potential underlying cause of Budd-Chiari syndrome in a patient, emphasizing the need for its consideration, especially in cases with multiple thromboemboli and thrombocytopenia.
1 citations
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October 2022 in “Molecular therapy” This study found that betibeglogene autotemcel significantly improved transfusion independence in 89% of patients with transfusion-dependent beta-thalassemia, although the high cost and manufacturing challenges may limit widespread adoption.
2 citations
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December 2019 in “Electronic Journal of General Medicine” This study found that combining microfocused ultrasound with autologous blood cell factors significantly improved skin rejuvenation compared to using microfocused ultrasound alone.