A Cross-Sectional Study Optimizing Platelet-Rich Plasma Preparation Using Various Centrifugation Speeds and Its Effects on the Platelet Yield

September 2024 in “ IP Indian Journal of Clinical and Experimental Dermatology ”

Vaishali S Makwana, Zeal Jayeshbhai Rachchha, Sandip Labhubhai Lathiya, N. Pandya

platelet-rich plasma centrifugation platelet yield PRP

TLDR The best method for high platelet yield is centrifuging at 1300 rpm then 1600 rpm.

This study aimed to optimize platelet-rich plasma (PRP) preparation by comparing different centrifugation protocols to determine which yields the highest platelet concentration. Conducted with 35 patients at a tertiary care hospital, the study found that centrifugation at 1300 rpm/246 g for 20 minutes followed by 1600 rpm/373 g for 20 minutes produced the highest platelet yield, achieving 4.6468 times the mean platelet count in whole blood. The results were statistically significant, highlighting the importance of selecting the appropriate centrifugation method to maximize therapeutic efficacy in PRP treatments.

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