September 2004 in “Experimental dermatology” This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.
June 1996 in “Irish Journal of Medical Science (1971 -)” This study found a statistically significant increase in glycosylated hemoglobins among patients with adult-acquired panhypopituitarism undergoing long-term GH replacement therapy, with two developing diabetes requiring treatment.
July 2008 in “British Journal of Dermatology” Cyclosporin doesn't stop hair loss.
2 citations
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May 2021 in “Bioengineering” This article reviews the evolving understanding of hematopoietic stem cells, including their heterogeneity and the role of cytokines in lineage determination, and reports no new results.
222 citations
,
January 2005 in “Endocrine journal” This article discusses the potential role of melatonin in protecting skin against stress and maintaining homeostasis, based on its local synthesis and various protective functions, but presents no new clinical results.
193 citations
,
February 2015 in “Nature Communications” Fungi-produced compounds can change plant root growth.
127 citations
,
January 2015 in “Journal of Biological Rhythms” This review discusses the role of the circadian clock in skin functions such as cell proliferation and UV protection and reports no new results; the authors note its potential in studying immune regulation and seasonal behaviors.
124 citations
,
October 2019 in “Frontiers in Immunology” This review discusses the role of the JAK-STAT pathway in autoimmune skin diseases and suggests potential therapeutic benefits of JAK inhibitors, but reports no new experimental results.
107 citations
,
December 2003 in “Dermatologic Therapy” This paper reviews the use of interferons, particularly alfa interferon, in treating cutaneous T-cell lymphoma, noting its substantial efficacy both alone and in combination therapies with predictable, generally well-tolerated side effects.
77 citations
,
July 2020 in “Journal of the European Academy of Dermatology and Venereology” This review examines the skin exposome, including solar exposure, air pollution, hormones, nutrition, and psychological factors, but reports no new clinical results.
57 citations
,
March 2019 in “Immunity” This review discusses the roles of immune responses and cells in skin health and disease, emphasizing recent insights into their mechanisms and potential therapeutic applications, but presents no new experimental results.
50 citations
,
March 2021 in “Journal of investigational allergology & clinical immunology” This review examines existing research and clinical trials on the use of dupilumab for various skin, respiratory, and gastrointestinal disorders, but it reports no new clinical findings.
25 citations
,
January 2019 in “Annals of Dermatology” This study observed that the NOTCH signaling pathway may contribute to the development of fibrosis in systemic sclerosis by affecting epithelial cell changes, and inhibiting this pathway could prevent fibrosis in experimental models.
16 citations
,
June 2017 in “Advances in Therapy” This review summarizes recent research on alopecia areata, highlighting advances in targeted therapies due to improved understanding of its immunopathogenesis, though it reports no new clinical results.
10 citations
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April 2020 in “Dermatology and therapy” In this study of 35 patients with scalp alopecia areata, calcipotriol ointment led to faster and greater hair regrowth than clobetasol, though differences were not statistically significant.
9 citations
,
January 2023 in “Dermatology and therapy” This case report describes a 14-year-old girl with alopecia universalis and mild atopic dermatitis who achieved complete hair regrowth and eczema resolution after three months of treatment with the JAK1 inhibitor upadacitinib.
9 citations
,
May 2005 in “Expert Review of Clinical Immunology” This article examines anticytokine therapies for autoimmune diseases, highlighting the potential of anti-interferon-γ as a universal treatment for certain conditions and noting varying effectiveness of tumor necrosis factor-α inhibitors.
8 citations
,
June 2019 in “Scientific Reports” This study found that the retinoid receptor and PPAR pathway are involved in hair follicle miniaturization in androgenetic alopecia, alongside androgen receptors.
6 citations
,
January 2022 in “GSC Biological and Pharmaceutical Sciences” This review discusses the ethnobotanical use and bioactivity of Eclipta prostrata, highlighting its potential in treating various conditions and linking its effects to secondary metabolites.
5 citations
,
April 2024 in “Journal of the Pakistan Medical Association” This study found that alopecia areata patients had significantly higher levels of interleukin-6 compared to healthy controls.
5 citations
,
December 2021 in “Physiological Research” This paper reviews the role of androgens in SARS-CoV-2 infection and their potential impact on disease severity, suggesting androgen-targeting strategies might influence outcomes, but reports no new clinical results.
4 citations
,
November 2023 in “Frontiers in immunology” In this narrative review, researchers outlined the role of T cells in the autoimmune pathogenesis of alopecia areata and highlighted ongoing research into therapeutic pathways, beyond current JAK inhibitors, aimed at developing new treatments for the disease.
2 citations
,
May 2023 in “Frontiers in immunology” This review highlights advances in understanding inflammatory memory in epidermal stem cells, focusing on their capacity to remember prior inflammatory responses and respond more quickly to future stimuli, potentially aiding strategies against skin-related diseases.
1 citations
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November 2025 in “Frontiers in Immunology” This review explores the complex role of the Innate Immune System in rheumatoid arthritis, highlighting gaps in understanding its functions and interactions with the Adaptive Immune System, offering insights into potential biomarkers and therapeutic strategies for this challenging autoimmune condition.
1 citations
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November 2024 in “Romanian Journal of Morphology and Embryology” This overview examines the biology, origin, structure, and function of various cells and structures, such as the blood-retinal barrier and Merkel cells, and discusses their roles in disease pathogenesis, along with recent findings related to the lymph nodes' paracortex.
1 citations
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April 2018 in “Journal of Investigative Dermatology” In this study, OEA was found to significantly enhance sebaceous lipogenesis and potentially reduce inflammation in human sebocytes, suggesting it as a promising candidate for treating skin dryness.
March 2026 in “Aging Research” This review provides a comprehensive synthesis of skin aging research, highlighting the interplay of genetic and environmental factors, cellular mechanisms, and advances in diagnostic and therapeutic strategies, while also addressing current debates and future directions in the anti-aging field.
March 2025 in “GSC Biological and Pharmaceutical Sciences” In this review, the authors examined the potential benefits of using wood tar in dermatology and cosmetics in Sub-Saharan Africa, based on its historical application in skin care and its worldwide usage.
January 2025 in “Open Life Sciences” This study observed that transgenic mice with overexpression of HE4 developed keratitis and severe corneal opacity, suggesting that HE4 may significantly influence keratopathy and inflammatory responses in the eye.
January 2024 in “International journal of pharmaceutical sciences review and research” This review paper critically evaluates the pharmacological and toxicological effects of Ziziphus mauritiana, a plant with traditional medicinal use, highlighting its anxiolytic, antioxidant, antimicrobial, anti-cancer, anti-diabetic, and anti-ulcer properties attributed to its rich phytochemical composition.