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Tofacitinib helped most patients with alopecia areata regrow hair and changes in immune cells were linked to the treatment's effectiveness.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

New melanoma treatments can cause skin side effects, including skin cancer and rashes, but combining treatments may reduce these risks.

Acne inversa is an epithelial-driven disease where inflammation is caused by cyst rupture, and treatments should focus on preventing tendril growth for better results.

Biologic treatments for Crohn's disease and ulcerative colitis can cause skin problems, and doctors should adjust treatment if these occur.

Platelet-rich plasma may help restore immune balance in bald patches, but its effectiveness in treating hair loss is limited.

Transplanting melanocyte stem cells from hair follicles can effectively treat vitiligo.

Mesenchymal Stem Cell therapy shows promise for treating hair loss in Alopecia Areata.

TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.

Contact immunotherapy might help treat various skin conditions, but more research is needed to confirm its safety and effectiveness.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.

Proteoglycans are important for hair growth, and a specific treatment can help reduce hair loss.

Cell-based models help test if cosmetic ingredients really work for hair growth and skin health.

Not having enough cystatin M/E protein causes less hair growth and dry skin.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Blood stem cells are diverse, influenced by many factors, and understanding them is key for progress in regenerative medicine.

The symposium highlighted the importance of understanding disease mechanisms for targeted dermatology treatments.

The document concludes that a complete skin restoration biomaterial does not yet exist, and more clinical trials are needed to ensure these therapies are safe and effective.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

Androgenetic alopecia involves immune cell disruptions, especially increased CD4+ T cells around hair follicles.

Air pollution (PM10) increases skin inflammation and aging by reducing collagen and may trigger a repair response in skin cells.

Epidermal keratinocytes start wound healing and inflammation after schistosome infection.

Rabbits with Sarcoptes scabiei had thicker skin, cell death, and skin hardening.

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.