Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study identified CXXC5 as a key mediator of hair loss induced by PGD2 and DHT via suppression of the Wnt/β-catenin pathway, with implications for potential therapeutic targets.

This study found that the topical Shen Bai hair growing decoction may improve androgenetic alopecia in mice by suppressing TNF-α and IL-6 levels, enhancing follicle density, and reducing apoptosis.

This study found that Monascus cursory extraction reduced baldness, prostate hyperplasia, and tumor incidence in animal models of androgen-related diseases, suggesting it may be a promising new therapeutic candidate.

This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.

In this study, androgen did not affect keratinocyte growth in coculture with androgenetic alopecia-derived dermal papilla cells, but did significantly suppress keratinocyte growth when androgen receptor was overexpressed in the papilla cells.

This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.

This study found that increased expression of type II 5α-reductase, androgen receptors, and Hic-5/ARA55 in dermal papilla cells upregulates androgen sensitivity, playing a key role in androgenetic alopecia pathogenesis.

This study discusses the use of oral contraceptives as a treatment for hyperandrogenism, showing improvement in hirsutism and acne for many women and possibly providing metabolic benefits with certain formulations.

This study found that finasteride significantly alters urinary steroid profiles, complicating the detection of steroid abuse in doping-control analysis by potentially causing false-negative results.

In this study, DHT was found to inhibit hair growth in mice by decreasing IGF-I production in dermal papillae through reduced sensory neuron stimulation.

This review discusses the hormonal influences on prostate carcinogenesis and notes ongoing trials investigating whether finasteride could reduce prostate cancer incidence by inhibiting dihydrotestosterone synthesis, but it reports no new results.

This article reviews idiopathic hirsutism, focusing on its definition, diagnosis, causes, and treatment options, without presenting new clinical findings.

In this study, the safety of finasteride in rats varied depending on dosing time, while its effectiveness on prostate weight reduction remained consistent.

Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

This study found that women with polycystic ovary syndrome had significantly lower levels of estradiol and follicle stimulating hormone compared to fertile women, with no significant differences in testosterone and thyroid hormone levels.

In this narrative review, researchers reported that oral finasteride significantly improved hair count and density in male androgenetic alopecia but had higher systemic exposure and potential side effects compared to topical formulations, which provided similar efficacy with lower systemic DHT suppression.

This study observed that pilose antler extract promoted hair growth in mice with androgenetic alopecia by stimulating the hair follicle growth cycle via the SHH/GLI pathway activation and BMP/Smad pathway suppression.

This study suggests that high nesfatin-1 levels and insulin resistance are linked to an increased risk and severity of acne vulgaris.

This review discusses the potential role of vitamin D deficiency in cardiovascular and renal diseases and suggests that supplemental vitamin D could benefit cardiovascular outcomes, especially in African American and postmenopausal women; it reports no new clinical findings.

In this study, Rosa rugosa water extract improved hair length and thickness in a mouse model of DHT-induced alopecia by enhancing the expression of hair growth-promoting factors while inhibiting growth-suppressive proteins, suggesting its potential as a natural therapy for hair loss prevention.

In this study, researchers developed a novel platform for discovering potential hair loss inhibitors by investigating the testosterone/dihydrotestosterone biosynthetic pathway and its regulation through biochemical mechanisms involving 17β-HSD and 3β-HSD, combined with medicinal plant extracts.

This literature review of hormonal implants in Brazil highlights their expanding usage beyond contraceptive and hormone replacement purposes, noting aesthetic desires like muscle mass gain. However, significant side effects such as cardiovascular events and psychological complications are frequently reported, potentially outweighing the benefits.

In this study, researchers found that crude extracts from Avicennia marina and its component avicequinone C inhibit mechanisms contributing to androgenic alopecia in vitro, including 5α-reductase activity and DHT-AR interactions, potentially promoting hair growth and delaying the catagen phase in human dermal papilla cells.

People with acne have more CD4+ immune cells in their skin than healthy people.

This review discusses the various phenotypes and diagnostic challenges of polycystic ovary syndrome, highlighting its complex pathophysiology and associated health risks, and reports no new clinical results.

This review provides a comprehensive overview of melatonin's physiological roles, effects, and clinical implications, but it does not present new experimental findings.

This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.

This review discusses factors affecting fertility in both men and women with congenital adrenal hyperplasia and emphasizes individualized preconception management but reports no new clinical results.

In this study, 17β-estradiol increased VEGF production in differentiated THP-1 cells, while dihydrotestosterone counteracted this effect by modulating adenylate cyclase activity.

This review discusses the management of androgenic disorders in women, highlighting that treatment is generally more effective than recognized, though improvement may take weeks or months to appear.