The Densities of T Cells, Langerhans Cells, and Natural Killer Cells in Uninvolved Skin of Patients with Acne Vulgaris

September 1997 in “ Journal of the European Academy of Dermatology and Venereology ”

A. Burhan Aksakal, Ayla Gülekon, Özlem Altay, Cem Sezer, Murat Orhan Öztaş

acne vulgaris T cells Langerhans cells natural killer cells CD3+ CD4+ CD8+ CD1a+ CD56+ epidermis dermis immunocytochemical methods acne helper T cells cytotoxic T cells skin immune cells

TLDR People with acne have more CD4+ immune cells in their skin than healthy people.

The study investigated the presence of various immune cells in the skin of patients with Acne Vulgaris (AV) compared to healthy controls. The researchers examined 25 biopsies, with 10 from moderate to severe acne cases and 15 from healthy subjects. They looked for the density of CD3+ (total T lymphocytes), CD4+ (helper/inducer T lymphocytes), CD8+ (suppressor/cytotoxic T lymphocytes), CD1a+ (Langerhans cells), and CD56+ (Natural Killer cells) in the epidermis and dermis using immunocytochemical methods. The results showed that only the CD4+ cells were statistically significantly elevated in the dermis of patients with AV compared to healthy subjects, with a p-value less than 0.05.

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