Search

for
Search:

Did you mean Testosterone?

Glossary Testosterone

hormone that regulates male traits and reproductive functions

Testosterone is a hormone primarily produced in the testes in men and in smaller amounts in the ovaries and adrenal glands in women. It plays a crucial role in the development of male reproductive tissues, the promotion of secondary sexual characteristics like increased muscle and bone mass, and the growth of body hair. Additionally, testosterone influences mood, energy levels, and overall well-being.

Related Terms

Sort by

Research

30 / 1000+ results

New Progesterone Esters as 5α-Reductase Inhibitors

research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.

22 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.

research Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors

13 citations , January 2005 in “Chemical and Pharmaceutical Bulletin”

This study reported that newly synthesized progesterone derivatives significantly reduced prostate weight in testosterone-treated hamsters, with 5alpha-reductase inhibitory activity dependent on the size of the substituent at C-17.

Proton Affinitive Derivatization for Highly Sensitive Determination of Testosterone and Dihydrotestosterone in Saliva Samples by LC-ESI-MS/MS

research Proton Affinitive Derivatization for Highly Sensitive Determination of Testosterone and Dihydrotestosterone in Saliva Samples by LC-ESI-MS/MS

8 citations , July 2018 in “Analytical sciences”

This study reported that derivatization with 5-butylpicolinic acid improved the sensitivity for detecting testosterone and DHT in saliva using LC-ESI-MS/MS, with minimal interference from the saliva matrix.

research Studies on the efficacy of methyl esters of n-alkyl fatty acids as penetration enhancers

3 citations , September 1989 in “Journal of Investigative Dermatology”

This study found that methyl nonanoate and methyl caprate significantly enhanced the skin penetration of minoxidil compared to solutions with other common enhancers like Azone, DMSO, or DEET.

research The Antiandrogenic Action of 4–Androsten–3–one–17β– Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ1

87 citations , April 1973 in “Endocrinology”

This study found that in hamster flank organs, 17βC inhibited enlargement caused by topical testosterone but not by DHT, suggesting potential use in androgen-related skin disorders like acne.

The Influence of Non-Esterified Fatty Acids on Ovarian Androgen Production in IVF – Preliminary Results

research The influence of non-esterified fatty acids (NEFA) on the ovarian production of androgens in a context of in vitro fertilisation (IVF) – preliminary results

August 2013 in “Fertility and Sterility”

This study found that women with PCOS have higher follicular fluid levels of testosterone and IL-6, despite similar NEFA levels to non-PCOS women, suggesting increased lipotoxicity impact on androgenesis in PCOS.

research Estimating the Contribution of the Prostate to Blood Dihydrotestosterone

28 citations , November 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study indicates that the normal human prostate is not a major contributor to circulating blood DHT concentrations in androgen-deficient patients receiving testosterone replacement therapy.

research New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature

19 citations , December 2021 in “Endocrine Reviews”

This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.

research Effects of hormonal treatment on dermatological outcome in transgender people: a multicentric prospective study (ENIGI)

11 citations , November 2022 in “Journal of Endocrinological Investigation”

In this study, gender-affirming hormonal treatment was associated with increased hair growth, acne, and alopecia prevalence in transgender individuals assigned female at birth, while opposite dermatological changes were observed in those assigned male at birth.

research Emerging drugs for hypogonadism

10 citations , October 2006 in “Expert Opinion on Emerging Drugs”

This review discusses trends in testosterone therapy use for male hypogonadism and reports no new clinical results, noting a shift towards more convenient and physiological treatments.

research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.

research In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5α-reductase inhibitors

27 citations , July 2008 in “The Journal of Steroid Biochemistry and Molecular Biology”

The new compounds may be more effective and cheaper than current treatments for conditions like baldness.

Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors

research Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.

23 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

This study found that several synthesized pregnane derivatives exhibited significant inhibitory effects on testosterone conversion to dihydrotestosterone and reduced related androgenic parameters in multiple pharmacological models.

research Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

12 citations , June 2024 in “Nutrients”

In this review, researchers highlighted that natural polyphenolics like flavonoids and resveratrol may help enhance testosterone production in aging males by boosting the expression of the Star gene in Leydig cells, potentially preventing age-related degenerative conditions linked to testosterone insufficiency.

research New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors

14 citations , June 2011 in “Steroids”

This study found that several dehydroepiandrosterone ester derivatives effectively reduced prostate and seminal vesicle weight in gonadectomized hamsters treated with testosterone, demonstrating potential antiandrogen effects comparable to Finasteride.

research In vitro assessment of some deodorant ingredients and determination of malodor inhibiting potentials of ascorbic acid, orlistat and mastic gum

June 2014 in “Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical Science”

This study reports that using ascorbic acid or orlistat can significantly inhibit the metabolism of testosterone esters into malodorous metabolites by axillary bacteria, suggesting potential new deodorant applications.

research Design, synthesis and anti-tumor evaluation of novel thiohydantoin congeners as androgen receptor antagonists with in vivo study.

May 2024 in “Journal of molecular structure”

This study found that a novel thiohydantoin derivative, 3a, effectively inhibited androgen receptor activity in LNCaP cells and showed promising in vivo results by reducing testosterone-induced prostate changes, outperforming finasteride in mitigating prostate index and histopathological alterations.

research 1 Androgens

29 citations , November 1975 in “Clinics in endocrinology and metabolism”

This article discusses the synthesis and action of testosterone and its interaction with specific receptors, reporting no new research findings.

research Steroids excreted by human skin. I. C19-steroids in axillary hair.

5 citations , January 1983 in “PubMed”

This study determined that in axillary hair of mature males and females, free androgen steroids are primarily produced by sebaceous glands, while C19-steroid sulphates are products of sweat glands.

research Children’s hair cortisol and hair testosterone concentrations in response to environmental changes: from summer holidays to school

3 citations , November 2021 in “Stress”

This study found that school-related stress increases hair cortisol in girls and alters hair testosterone and cortisol levels in boys, indicating gender-specific hormonal responses to environmental changes.

research Prevalence of polycystic ovaries in women with androgenic alopecia

84 citations , November 2003 in “European journal of endocrinology”

This study found that women with androgenic alopecia had a higher prevalence of polycystic ovarian morphology and higher androgen levels compared to controls, suggesting a strong association with PCO.

research Potential adverse effects of long-term testosterone therapy

72 citations , October 1998 in “Baillière's clinical endocrinology and metabolism”

This article discusses the potential effects of exogenous testosterone, highlighting that its impact on prostate cancer progression, cardiovascular health, and behavior remains uncertain and needs further investigation.

research Testosterone and doping control

103 citations , June 2006 in “British journal of sports medicine”

This review discusses the use of anabolic-androgenic steroids in sports and outlines current methods for detecting urinary steroid doping, particularly testosterone, but reports no new experimental findings.

Changes in Serum Free Testosterone, Sleep Patterns, and 5-Alpha-Reductase Type I Activity Influence Sebum Excretion in Female Subjects

research Changes in serum free testosterone, sleep patterns, and 5‐alpha‐reductase type I activity influence changes in sebum excretion in female subjects

10 citations , August 2014 in “Skin research and technology”

This study found that variations in sleep patterns, free testosterone, and 5-alpha-reductase type 1 activity are associated with changes in sebum excretion in women, which may contribute to variability in acne studies.

Effect of the Frequency of Injection on the Clinical Responses of Postmenopausal Women to Testosterone Enanthate with Estradiol Valerate

research Effect of the frequency of injection on the clinical responses of postmenopausal women to testosterone enanthate with estradiol valerate

May 1963 in “American journal of obstetrics and gynecology”

This study found that a single 2 ml injection of TEEV every 4 weeks offers similar beneficial effects with fewer side effects compared to injecting the same dose every 2 weeks in postmenopausal women.

research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin

34 citations , February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.

Human-Derived Immortalized Dermal Papilla Cells With Constant Expression of Androgen Receptor

research Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor

8 citations , March 2020 in “Frontiers in Cell and Developmental Biology”

This study developed a DPC cell line by introducing mutant CDK4, Cyclin D1, and TERT, making it a promising tool to study downstream signaling pathways activated by testosterone in androgenetic alopecia.

Exogenous Testosterone Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum Testosterone

research Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T

506 citations , March 2005 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that testosterone therapy improved physical performance and strength in older men with low testosterone over 36 months, whether administered alone or with finasteride.

Testosterone Therapy for Transgender Men: Effects and Safety

research Testosterone therapy for transgender men

162 citations , April 2016 in “The Lancet Diabetes & Endocrinology”

This review discusses the effects of testosterone therapy for transgender men, noting desired outcomes and potential risks, but reports no new research findings; the authors highlight a lack of high-quality data due to various study limitations.

research Safety of testosterone treatment in postmenopausal women

81 citations , May 2007 in “Fertility and Sterility”

This review discusses the safety of testosterone therapy for postmenopausal women and concludes that, aside from hirsutism and acne, it appears safe at physiological doses for several years, though more long-term studies are needed.