Evaluation of Efficacy, Safety, and Reversibility of Combination Regimen of Cyproterone Acetate and Testosterone Buciclate in Bonnet Monkeys

    October 2000 in “ Contraception ”
    Radhey Shyam Sharma, M. Rajalakshmi, P. C. Pal, Somnath Roy, V.K Behal, Dipika Sharma, P. K. Chaturvedi, Jatinder Pruthi
    Image of study
    TLDR The right dosage of CPA and TB can work as a safe and reversible male contraceptive in monkeys.
    In a study from 2000, researchers tested a contraceptive regimen combining cyproterone acetate (CPA) and testosterone buciclate (TB) on bonnet monkeys. Group II, with 6 monkeys, received 5 mg CPA daily and 40 mg TB at specific intervals, achieving azoospermia by day 120, which lasted until day 210, with sperm levels returning to baseline by day 330. Group III, also with 6 monkeys, received the same CPA dose but a higher TB dose (80 mg) and did not achieve consistent azoospermia, nor did sperm concentration return to baseline by the study's end. Elevated serum testosterone levels in both groups normalized by day 330, and no significant changes in lipid profiles or liver function were observed, indicating safety. The study concluded that the right dosage of CPA and TB can be an effective, safe, and reversible male contraceptive method.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 81 results

      community Spironolactone for hair loss??

      in Product  6 upvotes 2 years ago
      Hair loss treatments discussed include Minoxidil, Finasteride, and Spironolactone. One user shares success with Finasteride, Minoxidil, and low-dose Cyproterone Acetate, but warns against long-term use of oral anti-androgens.

      community Extreme regimen and still miniaturized hairs. AGA is just impossible to beat.

      in Insane  35 upvotes 1 year ago
      A user's extreme regimen for hair loss, which includes taking oral and topical medications such as minoxidil, dutasteride, cyproterone acetate and bicalutamide, but still experiencing miniaturization. Suggestions were made to try other treatments such as RU58841 and Pyrilutamide, while also considering mental health treatment and advice on lookmaxxing.

      community Are these all the anti androgen products?

      in Treatment  6 upvotes 1 year ago
      The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

      community 5 months of nuking T, 2 months of minoxidil

      in Transgender  485 upvotes 2 months ago
      The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.

    Similar Research

    5 / 1000+ results