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Overexpressing follistatin in mice delays wound healing and reduces scar size.

Hair growth and development are controlled by specific signaling pathways.

GPRC5D is linked to the formation of hair, nails, and certain tongue areas.

Improved understanding of stem cell mechanisms can enhance skin tissue engineering.

Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.

Autophagy helps keep skin healthy and may improve treatments for skin diseases.

The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.

The Notch signaling pathway is important for hair follicle development and could help create treatments for hair disorders.

WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.

Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

Growth factors are crucial for hair development and could help treat hair diseases.

New vitamin D3 forms need the vitamin D receptor to reduce fibrosis in human cells.

DPP4-positive fibroblasts play a major role in producing proteins that lead to skin fibrosis.

Fractional photothermolysis helps wounds heal with minimal scarring.

BRG1 is essential for skin cells to move and heal wounds properly.

The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.

Hair loss caused by genetics and hormones; more research needed for treatments.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Different types of skin cells play specific roles in development, healing, and cancer.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.