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This study found that allergen treatment in alopecia areata mice appeared to alter leukocyte subset distribution and impaired dendritic cell migration, which may affect T-cell activation and hair follicle recovery.

This review discusses the role of natural killer cells in the pathogenesis of blistering diseases and proposes further research on their interaction with the skin, reporting no new clinical results.

This study reports that OKT6-positive dendritic cells increase in hair follicles during progressive alopecia areata, suggesting a potential role in disease pathogenesis through interaction with T cells.

This review discusses how recent studies use models and experiments to understand immune system signaling, but it reports no new clinical findings; the authors suggest strategies for improving these models.

This study found that transgenic cashmere goats overexpressing thymosin beta-4 have a higher secondary to primary hair follicle ratio, suggesting potential for increased cashmere yield.

This study found that selectively targeting HDAC4 and HDAC7 in mice can reduce Th17 cell-mediated intestinal inflammation, suggesting a potential treatment approach for Th17-related inflammatory diseases like ulcerative colitis.

This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.

The study suggested certain immune cells might cause alopecia areata, but it was retracted.

This study suggests that increased T cell blastogenesis may predict a positive response to topical 5% minoxidil treatment in patients with severe alopecia areata.

This study found that wounds in dogs treated with allogeneic adipose-derived mesenchymal stem cells showed faster and improved healing compared to wounds receiving conventional treatment.

This study found that immune cells, including T cells and macrophages, significantly influence stem cell behavior and tissue regeneration by secreting cytokines and inflammatory factors in mice.

In this study, researchers prepared a humanized CXCL12 antibody for alopecia areata treatment, finding it significantly delayed disease onset in mice and reduced immune cell activation, suggesting potential as an immune modulatory therapy.

This study reported that using UVB preirradiation and anti-CD154 antibody treatment in a humanized mouse model prolonged hair follicle allograft survival and reduced immune cell infiltration without needing generalized immunosuppression.

This study used digital-light-processing bioprinting to create a 3D skin-on-a-chip model with a miniaturized vascular network to closely study immune cell interactions similar to real human skin, demonstrating the potential to analyze immune-T cell trafficking influenced by skin signals.

This review discusses the roles of distinct immune cell types in skin wound healing, highlighting findings from animal studies, but provides no new clinical results.

This review explores how mesenchymal stem cells and their extracellular vesicles may treat various skin diseases by modulating immune responses and promoting healing, though further clinical trials are needed to confirm their safety and efficacy in practice.

In this study, researchers reported that a newly developed interferon-γ release assay for cell-mediated immunity to SARS-CoV-2 nucleocapsid peptides demonstrated high sensitivity and specificity, making it a robust tool for routine diagnostic tests and potentially useful in predicting clinical outcomes after pathogen re-exposure.

In this study, only a subset of proposed biomarkers universally responded to priming in mesenchymal stromal cells, suggesting limited utility for standardized potency assays across different MSC types and conditions.

This article reviews the emerging non-inflammatory roles of regulatory T cells in the skin and reports no new clinical findings, suggesting broad biological influence beyond traditional immune functions.

In this study, the researchers reported that using a biodegradable ECM scaffold for large-area wound regeneration accelerated wound coverage and improved hair follicle neogenesis by activating the adaptive immune system.

This study found that fibroblast loss in the upper dermis from UVR exposure is linked to a deregulated inflammatory response, with T cells playing a protective role in fibroblast survival.

This study found that topical simvastatin induced remission and hair regrowth in a mouse model of alopecia areata, potentially by modulating T cell activity and reducing pro-inflammatory cytokine signaling.

Alopecia totalis/universalis involves more intense immune activity and inflammation than patchy alopecia areata.

This mini-review reports that advances in microbioreactor technology, particularly with microfluidics, significantly enhance eukaryotic cell-based biomedicine by improving productivity, scalability, and reproducibility in applications like CAR T-cell manufacturing and organoid growth, though challenges in scalability and material selection remain.

In this single-cell transcriptomic study, researchers analyzed AA scalp samples and found distinct immune and nonimmune cell activation patterns, with elevated TH1/TH2 and JAK/STAT markers potentially contributing to hair follicle immune privilege disruption and disease severity.

In this study, distinct immune and cellular profiles were observed in adults with atopic dermatitis associated with high levels of Staphylococcus aureus, including increased proinflammatory T cells and markers of skin barrier impairment, pointing to potential therapeutic targets for managing these interactions.

This study reviewed evidence on biologic drugs targeting immune cells for alopecia areata, finding mixed results: some achieved case-level hair regrowth, but controlled trials often showed limited efficacy.

Alopecia areata involves complex immune cell interactions, especially between CD8+ T cells and macrophages, which could help develop new treatments.

This study examined interactions between immune cells and dermal papilla cells in a patient with alopecia areata using single-cell RNA sequencing; it identified specific T cell subtypes and ligand-receptor pairs that may contribute to hair cycle disruption through inflammation.

Brepocitinib improves cicatricial alopecia and reduces key immune markers.