research The Promise and Challenges of Cell Therapy for Psoriasis
Cell therapy shows promise for treating severe psoriasis but needs more research to confirm safety and effectiveness.
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research Disturbance of Immune Microenvironment in Androgenetic Alopecia Through Spatial Transcriptomics
Androgenetic alopecia involves immune cell disruptions, especially increased CD4+ T cells around hair follicles.
research Braicitinib Treatment Reduced the Expansion of CD8+ T Cells in C3H Mice With Skin Grafts-Induced Alopecia Areata
Baricitinib treatment helped reduce hair loss symptoms in mice by decreasing inflammation-related immune cells.
research Surgical Approaches for Repigmenting Vitiligo 2.0
Assessing CD8+ T cell levels before surgery may improve vitiligo treatment outcomes.
research Single-Cell Transcriptomics Reveals Distinct Molecular Programs in Folliculotropic Mycosis Fungoides
Folliculotropic mycosis fungoides has unique molecular features and cell interactions that could guide targeted therapy.
research Cell Population Dynamics in Wound-Induced Hair Follicle Neogenesis Model
Non-immune dermal cells dominate, epidermal cells increase after day 9, and certain immune cells persist beyond inflammation in wound-induced hair follicle regeneration.
research Resident Memory T Cells in Autoimmune Skin Diseases
Certain immune cells contribute to skin autoimmune diseases, and some treatments can reverse hair loss in these conditions.
research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients
Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.
research Follicular Mycosis Fungoides Mimicking a Cutaneous B-Cell Lymphoproliferative Disorder
Follicular mycosis fungoides can look like a B-cell lymphoma, making diagnosis difficult.
research Spectrum of Mucocutaneous Manifestations in HIV-Infected Patients and Its Correlation with CD4 Lymphocyte Count
HIV patients with lower CD4 T cell counts often have more skin problems.
research The Expanding Impact of T-Regulatory Cells in Skin Health
T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
research Impact of the COVID-19 Pandemic on Tertiary Care University Dermatology Outpatient Clinic and Dermatology Procedures
The COVID-19 pandemic led to fewer patient visits, more visits by older adults, an increase in cutaneous T-cell lymphoma cases, and a rise in noncosmetic procedures at a dermatology clinic.
research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche
Lichen planopilaris may be an autoimmune disease causing hair loss due to immune system issues in hair follicles.
research Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels
CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
research Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro
Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.
research Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease
Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.
research Simvastatin Reduces Autoimmune Alopecia Through Direct Action on T Lymphocytes
Simvastatin helps hair regrowth in autoimmune alopecia by directly affecting T cells.
research Down-Ranking the Threat of HSV-1: RANKL Upregulates MHC Class I Restricted Anti-Viral Immunity in Herpes Simplex Virus Infection
RANKL improves the immune response against herpes simplex virus by enhancing T cell activation and could help develop better treatments or vaccines.
research SLE and Serum Complement: Causative, Concomitant or Coincidental?
Low serum complement levels in SLE patients don't always match with disease flares; monitoring C3 and C4 is useful, but cell-bound complement products might better indicate disease activity.
research Significance of HLA-DR+ T Cells and Natural Killer Cells in the Peripheral Blood Lymphocytes of Alopecia Areata
Severe alopecia areata involves higher levels of certain immune cells, which can be normalized with betamethasone.
research Phenotypic Analysis of T-Cells in Extensive Alopecia Areata Scalp Suggests Partial Tolerance
T-cells in alopecia areata scalp show abnormal regulation, leading to less inflammation.
research Scarring Hair Follicle Destruction Is Driven by the Collapse of EGFR-Protected JAK-STAT1-Sensitive Stem Cell Immune Privilege
A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.
research Regulatory T Cells in Inflammatory Skin Disease: From Mice to Humans
Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.
research Dusko Ilic Explores the Latest Developments in the Field of Stem Cell Research and Regenerative Medicine
Stem cell research and regenerative medicine have made significant advancements in treating various diseases and conditions.
research More Expression of IL-17 Than IFN-γ from CD49a-Negative Tissue-Resident Memory T Cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients According to the Foxp3+ mTregs Depletion
IL-17 and certain immune cells are linked to more severe alopecia areata.
research Human αβ and γδ T Cells in Skin Immunity and Disease
Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.
research Perforin Expression by Cutaneous Gamma Delta T Cells
Gamma delta T cells in the skin help with healing and defense but can also cause autoimmune issues, and more research is needed to understand how they are activated.
research Industry Updates from the Field of Stem Cell Research and Regenerative Medicine in December 2019
Significant progress and collaborations in stem cell research and regenerative medicine were made, including advancements in hair growth, cancer therapies, and treatments for neurological disorders.
research Human Regulatory Gamma Delta T Lymphocytes as Novel Autoimmunity-Protective Cells: Lessons from Alopecia Areata
γδTregs may help treat autoimmune diseases like alopecia areata by promoting hair regrowth and reducing immune attacks.
research Local Heroes or Villains: Tissue-Resident Memory T Cells in Human Health and Disease
Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.