Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that a 5-mg daily dose of transdermal testosterone cream in postmenopausal women restored testosterone levels to those typical of premenopausal women.

This study found that mental rotation and neuroticism demonstrated curvilinear relationships with hair loss, suggesting that dihydrotestosterone levels might affect spatial cognition and personality traits in men.

This study found that finasteride improves scalp hair growth in men with male pattern hair loss by reducing scalp dihydrotestosterone levels, but it did not benefit postmenopausal women with female pattern hair loss.

This study systematically reviewed the use of topical testosterone products such as creams, gels, and patches, finding they effectively raise serum testosterone but pose significant systemic risks like acne and gynecomastia, necessitating careful medical oversight.

This review found that women with idiopathic hirsutism may have increased 5α-reductase activity, as indicated by elevated levels of a dihydrotestosterone-reduced metabolite, but more research is needed to confirm its clinical relevance as a biomarker.

This study observed that among male patients who experienced telogen effluvium after platelet-rich plasma treatment for androgenic alopecia, there were elevated levels of TNF-α, androgen receptors, and altered 5α-reductase gene expression, suggesting these factors as potential contributors to this unintended outcome.

This study observed that herbal feed supplementation in Frieswal breeding bulls improved semen volume and motility, while significantly lowering dihydrotestosterone levels, suggesting a potential mechanism for enhancing semen quality.

In this study, co-administration of finasteride with oral testosterone undecanoate in young men with induced hypogonadism had no significant effect on serum testosterone or dihydrotestosterone levels, likely due to TU's unique absorption route.

This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.

This study evaluated androgen-induced hair loss and anagen induction mouse models, finding that Minoxidil and Pyrilutamide significantly promoted hair growth by decreasing androgen receptor protein levels and enhancing the Wnt/β-Catenin signaling pathway, supporting their use in studying novel treatments for androgenetic alopecia.

This study found that combining fire needle therapy with DHT treatment over eight weeks improved lesion severity, scar symptoms, quality of life, and reduced serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.

This review posits that alopecia in PCOS results from the interaction between local follicular signaling failures, insulin resistance, inflammation, and genetic predispositions, rather than solely from androgen excess, and recommends a systems-level framework for its management.

This study found that low androgen levels in rat penile endothelial cells were associated with a decrease in eNOS-expressing extracellular vesicles and reduced nitric oxide production.

This study found that in vitro environments simulating testosterone levels in elderly males, testosterone and its metabolite DHT significantly reduced macrophages' ability to phagocytize MRSA and Pseudomonas aeruginosa, suggesting AR manipulation and inhibiting testosterone-DHT conversion might help fight wound infections in the elderly.

This study found that low serum testosterone and elevated serum oestrone in men with cirrhosis are associated with worse liver disease and adverse health outcomes, suggesting oestrone as a potential ill health marker.

This study found that the HPCH-based formulation P-08–016 may facilitate finasteride deposition in the dermis, potentially offering an alternative to systemic therapy by minimizing systemic absorption.

In this study, a novel compound named AH-001 demonstrated effective androgen receptor protein degradation, reducing hair loss progression in a mouse model of androgenetic alopecia, with minimal systemic exposure and side effects, suggesting potential for safer treatment.

This study observed that using only a 5 alpha-reductase inhibitor was ineffective for treating androgen-dependent hair loss in women, possibly due to differing copper levels influencing enzyme activity.

In this narrative review, researchers reported that oral finasteride significantly improved hair count and density in male androgenetic alopecia but had higher systemic exposure and potential side effects compared to topical formulations, which provided similar efficacy with lower systemic DHT suppression.

This review discusses the efficacy and safety of oral finasteride for treating male pattern baldness and the potential persistent side effects, but no new results are reported.

This study found that early life stress significantly affects hedonic sensitivity to high-palatable food by altering gonadal hormones in prenatally-stressed male and female rats, with sex-dependent changes in reward-related behaviors and neurochemistry.

This article discusses the potential use of 5α-reductase inhibitors in dermatology and reports no new clinical results; the authors suggest further exploration of their dermatological applications.

In this study, creatine supplementation over 12 weeks showed no effect on androgen levels or hair follicle health in healthy young males, challenging the belief that creatine causes hair loss.

This study found that sleep deprivation in mice can trigger prostatitis by activating the cGAS-STING pathway due to reduced levels of dihydrotestosterone and melatonin, resulting in a pro-inflammatory environment, while recovery sleep can mitigate these effects.

This chapter reviews ethosomes for targeted drug delivery to the scalp in androgenetic alopecia and reports no clinical results; the authors emphasize reducing systemic side effects.

This review evaluates dihydrotestosterone's role in androgenic alopecia and proposes a model suggesting that chronic scalp tension and inflammation contribute to hair follicle miniaturization, identifying fibrosis, calcification, and tension as treatment targets.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

This study found that finasteride treatment improved cardiac function and reduced heart failure progression in mice, suggesting it could be a potential therapy for pathological cardiac hypertrophy and dysfunction.

This review summarizes existing research on the use of finasteride for treating androgenetic alopecia in men, reporting its effectiveness at 1 mg/day and a strong safety profile, but presents no new findings.

This study found that a topical combination of 0.25% finasteride and 3% minoxidil may increase hair diameter more effectively than 3% minoxidil alone in postmenopausal women with female pattern hair loss.