Efficacy of Fire Needle Therapy Combined with Doxycycline Hydrochloride in the Management of Moderate-to-Severe Acne Vulgaris: A Randomized Controlled Trial
November 2025
in “
Journal of Multidisciplinary Healthcare
”
TLDR Combining fire needle therapy with doxycycline improves severe acne more than doxycycline alone.
A randomized controlled trial conducted over 8 weeks demonstrated that combining fire needle therapy with doxycycline hydrochloride (DHT) significantly improved lesion severity, scar symptoms, quality of life, and serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.
