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Human enzymes can detoxify harmful substances but might also increase their cancer risk.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Hair loss in balding individuals is linked to changes in specific hair growth-related genes.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.

TGF-β2 plays a key role in human hair growth and development.

Combined minoxidil and tretinoin solution works as well as regular minoxidil for male hair loss.

Low-dose oral minoxidil safely treats hair loss, with hypertrichosis as main side effect.

Minoxidil lowers blood pressure, increases heart rate, and improves blood flow in dogs.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Potassium channel openers like minoxidil help hair grow by acting on hair follicles.

Combining low-level light therapy and minoxidil 5% is more effective for female hair loss than using either treatment alone.

Minoxidil affects cell growth in two ways: low doses increase growth, while high doses slow it down and can be toxic.

Thyroid hormones are important for skin health and might help treat skin diseases, but more research is needed to understand their effects fully.

Scalp hair follicle culture has limits for testing minoxidil's hair growth effects.

Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.

Sp6 promotes tooth development by reducing follistatin levels.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Thyroid hormones affect skin texture, hair and nail growth, and can cause skin diseases related to thyroid problems.

Colchicine can inhibit hair growth by affecting cell activity and protein expression in hair follicles.

Older rats more affected by minoxidil's cardiotoxic effects than younger rats.

Understanding hair follicle biology and stem cell control could lead to new hair loss treatments.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Over 67 genes linked to ichthyosis help improve diagnosis and treatment.

The enzyme PST is found in developing human kidneys and helps with detoxification and development.