May 2026 in “International Journal of Homoeopathic Sciences” In this case report, a middle-aged female patient experienced significant improvement in chronic telogen effluvium symptoms, including reduced hair fall and improved hair density, following an individualized homeopathic treatment at Dr. Batra’s, highlighting the role of addressing emotional, metabolic, and nutritional factors.
4 citations
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February 2022 in “Frontiers in molecular biosciences” This study revealed that chronic restraint stress in mice led to significant alterations in metabolic pathways and gene expression associated with hair growth inhibition, using metabolomics and transcriptomics analyses.
21 citations
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January 1988 in “Stress Medicine” This review discusses the developmental and psychological significance of skin and emphasizes the need for considering stress effects when evaluating and treating psychocutaneous diseases, without reporting new clinical results.
73 citations
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January 2013 in “European journal of dermatology/EJD. European journal of dermatology” This review examines current research on antioxidants in autoimmune skin diseases like alopecia areata and vitiligo, concluding with suggestions for future studies and treatment possibilities without reporting new clinical results.
January 2025 in “JOURNAL of SIBERIAN MEDICAL SCIENCES” This review highlights morphological factors contributing to age-related alopecia and suggests further research to understand and potentially mitigate cellular aging processes affecting hair quality.
13 citations
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December 2016 in “Journal of Cosmetic Dermatology” This study found increased oxidative stress in younger male patients with early-onset androgenetic alopecia compared to healthy peers, suggesting a potential role for antioxidants in their treatment.
40 citations
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May 2014 in “PLoS ONE” This study suggests that chronic stress can lead to decreased skin pigmentation in mice by disrupting the skin's HPA axis, potentially making stress a risk factor for depigmentation.
30 citations
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December 2011 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that serine 44 in the N-terminal head domain of keratin 17 is phosphorylated in response to various stimuli affecting skin keratinocyte growth, linking K17 up-regulation with growth and stress responses in skin epithelium.
16 citations
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May 1998 in “International Journal of Dermatology” This study found that elevated serum cortisol levels and other immunological changes are significantly involved in the active phases of psoriasis eruptions.
2 citations
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January 2013 in “Advances in Experimental Medicine and Biology” This study found that taurine may have potential as an anti-alopecia agent, particularly against chemical stress-induced hair loss, and could be effective when used with other treatments like finasteride.
January 2025 in “Journal of Veterinary Medical Science” In this study, researchers observed that genetically identical cloned dogs, when exposed to different environments like an airport and a police station for two years, exhibited significant differences in toxic mineral concentrations and intestinal microbiota composition, suggesting that environment influences physiological traits even among clones.
215 citations
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March 2018 in “Archives of Toxicology” This study found that PM2.5 exposure induced oxidative stress in human keratinocytes and mouse skin, causing cellular damage, which was mitigated by the antioxidant N-acetyl cysteine.
34 citations
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April 2014 in “Psychopharmacology” This review discusses the pharmacological properties and physiological regulation of neuroactive steroids, focusing on their varied responses to stress and ethanol in rats, mice, and humans, but it reports no new findings.
59 citations
,
November 2015 in “International Journal of Cosmetic Science” This review considers oxidative stress effects on hair aging and emphasizes the need for dermatologists to recognize and treat factors affecting scalp and hair health, but it provides no new clinical findings.
In this study, a Monte Carlo-generated synthetic cohort analysis found that higher simulated cannabis exposure was linked to increased self-assessed hair loss severity and reduced follicular density, suggesting potential connections worth exploring in further clinical research.
280 citations
,
July 2018 in “Antioxidants” This review discusses the role of reactive oxygen species in wound healing, highlighting potential strategies like mitochondrial-targeted antioxidants for managing non-healing chronic wounds, and reports no new clinical results.
7 citations
,
January 2020 in “Nature” This study found that stress-induced signaling from the sympathetic nervous system in mice led to the depletion of stem cells in hair follicles, resulting in premature greying.
August 2025 in “International Journal For Multidisciplinary Research” This study highlights that stress and coping styles significantly influence the symptom severity of Indian women with PCOS, emphasizing a need for culturally appropriate interventions to improve quality of life.
65 citations
,
May 2010 in “Current Women's Health Reviews” This review discusses oxidative stress's role in polycystic ovary syndrome and examines various biomarkers to understand its impact on the disorder's pathogenesis, but reports no new clinical results.
12 citations
,
September 2024 in “Frontiers in Immunology” This study found that metabolism-related genes significantly impact the prognosis and metastasis in breast cancer, and the development of prediction models may guide personalized therapeutic strategies.
October 2025 in “Brazilian Journal of Hair Health” This narrative review identifies telogen effluvium as a growing concern linked to weight-loss interventions, such as GLP-1 receptor agonists and bariatric surgery, attributing hair loss to systemic and metabolic stress rather than permanent hair follicle damage.
August 2024 in “Biomolecules & Therapeutics” In this study, the researchers reported that a newly developed PYGL inhibitor, HTPI, enhanced hair growth in an ex-vivo culture by reducing oxidative damage in hDPCs and inhibiting glycogen degradation in hORSCs, showing potential as a treatment for hair loss comparable to minoxidil.
October 2023 in “Research Square (Research Square)” In this study, researchers found that patients with new-onset mild alopecia areata had higher levels of oxidative stress markers and reduced antioxidant levels compared to healthy individuals, suggesting that oxidative stress might play a role in the condition.
3 citations
,
June 2021 in “Journal of affective disorders” This study suggests that hair cortisol and cortisone may moderate the relationship between work stress and depressive symptoms in Chinese fishermen, although their mechanisms differ.
May 2023 in “Animal Reproduction Update” This article reviews the use of hair cortisol concentration as a biomarker to assess long-term stress in both animals and humans, but it reports no new experimental results.
25 citations
,
June 2017 in “Scientific reports” This study suggests that stress may worsen Tourette syndrome symptoms in mice by increasing allopregnanolone synthesis, with findings supporting finasteride as a potential treatment to manage symptom fluctuations.
This study found that inhibiting the Mitochondrial Pyruvate Carrier in human scalp hair follicles caused metabolic stress that halted cell proliferation and disrupted key signaling pathways, with these effects partially reversed by an integrated stress response inhibitor.
July 2026 in “Clinical Cosmetic and Investigational Dermatology” In this cross-sectional study of healthy urban women in Shanghai, poor sleep quality and elevated perceived stress were linked to various self-reported dermatological issues and clinical signs, reinforcing the potential relevance of psychological factors in skin health.
64 citations
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June 2020 in “PLoS ONE” This study found that red light exposure significantly enhanced the growth, phytochemical content, and therapeutic potential of Eclipta alba callus cultures compared to other multispectral light exposures.
This study found that oxidative stress markers, specifically MDA and H2O2, along with decreased SOD activity, may play a key role in the development of diffuse hair loss in the studied population.