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Glossary Stimulant

A stimulant is a substance that increases activity in the central nervous system, which can lead to heightened alertness, energy, and mood elevation. In the context of hair loss, certain stimulants, such as caffeine, are believed to promote hair growth by increasing blood circulation to the scalp and potentially prolonging the anagen (growth) phase of hair follicles. Key distinguishing characteristics of stimulants include their ability to enhance metabolic processes and their varying effects on individual hair growth responses, making them a topic of interest in hair biology and treatment strategies for hair loss.

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research A fast liquid chromatographic/mass spectrometric screening method for the simultaneous detection of synthetic glucocorticoids, some stimulants, anti‐oestrogen drugs and synthetic anabolic steroids

100 citations , October 2006 in “Rapid Communications in Mass Spectrometry”

This study describes a fast LC/MS/MS method for detecting various synthetic drugs in urine, meeting World Anti-Doping Agency performance limits.

research Association of Alopecia Areata With Attention-Deficit/Hyperactivity Disorder Stimulant Medication: A Case-Control Study

January 2021 in “The Ochsner journal”

In this study, researchers found a significant association between attention-deficit/hyperactivity disorder stimulant medications and alopecia universalis in children, although this finding was based on a small sample size.

Stimulating Effect of Adrenalectomy on Hair Growth and Melanin Deposition in Black Rats Fed Diets Adequate and Deficient in the Filtrate Factors of Vitamin B1

research STIMULATING EFFECT OF ADRENALECTOMY ON HAIR GROWTH AND MELANIN DEPOSITION IN BLACK RATS FED DIETS ADEQUATE AND DEFICIENT IN THE FILTRATE FACTORS OF VITAMIN B¹

34 citations , January 1943 in “Endocrinology”

In this study, adrenalectomy in rats on a diet lacking certain vitamin B components reversed fur graying and enhanced hair growth.

research Stimulate Hair Growth in Miami _82

September 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

research 890 Impact of a stimulating cream shampoo treatment on the penetration of minoxidil through hair follicles

April 2017 in “Journal of Investigative Dermatology”

This study found that pre-treatment with a stimulating cream shampoo significantly increased Minoxidil penetration into hair follicles and the scalp compared to using Minoxidil alone.

research 558 Impact of a stimulating cream shampoo treatment on the penetration of minoxidil through hair follicles

April 2016 in “Journal of Investigative Dermatology”

This study found that a stimulating cream shampoo enhances the penetration of Minoxidil into hair follicles and scalp in a laboratory setting.

research Stimulating effect of adrenalectomy on hair growth and melanin deposition in black rats fed diets adequate and deficient in the filtrate factors of vitamin B. With a note on effect of diet on post-operative survival.

January 1943

The Decrease of Minoxidil 1% Side Effects by Using Herbal Stimulants in Cerita Hair Tonic

research The decrease of the Minoxidil 1% side effects by using herbal stimulants in cerita hair tonic

August 2014 in “Journal of clinical & experimental dermatology research”

This study found that using Cerita anti hair loss tonic significantly reduced daily hair loss in men compared to a temple lotion, suggesting potential benefits of herbal stimulators in addressing androgenic hair loss.

research Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells

33 citations , November 1994 in “Archives of Biochemistry and Biophysics”

research Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

145 citations , November 2018 in “Nature Communications”

This study found that activating the Sonic hedgehog pathway in scarring wounds can remodel the dermis to promote hair follicle regeneration, highlighting a potential new approach to enhance healing.

Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations , May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

research Mycorrhiza stimulates root-hair growth and IAA synthesis and transport in trifoliate orange under drought stress

131 citations , January 2018 in “Scientific Reports”

In this study, mycorrhizal fungal inoculation was associated with increased root-hair growth and enhanced drought tolerance in trifoliate orange by modulating auxin synthesis and transport under water stress conditions.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations , March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

research Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones

105 citations , February 2010 in “Endocrinology”

This study found that normal human epidermis expresses TSH and may be an indirect target of TSH signaling, with expression regulated by endocrine controls of the hypothalamic-pituitary-thyroid axis.

research Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles

95 citations , August 2013 in “Journal of Investigative Dermatology”

HPT axis hormones boost mitochondrial function and growth in hair follicles, potentially aiding hair health.

research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

90 citations , December 2008 in “Journal of Investigative Dermatology”

Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.

Dihydrotestosterone Stimulates 5α-Reductase Activity in Pubic Skin Fibroblasts

research Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts*

57 citations , February 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that pubic skin fibroblasts respond to androgens, increasing 5α-reductase activity via an androgen receptor-mediated mechanism, suggesting its potential as a marker of androgen action in vitro.

research Testosterone stimulates proliferation and inhibits interleukin‐6 production of normal and hereditary gingival fibromatosis fibroblasts

39 citations , May 2002 in “Oral Microbiology and Immunology”

In this study, dihydrotestosterone increased proliferation and decreased IL-6 production in in-vitro fibroblasts from hereditary gingival fibromatosis and normal gingiva, effects partially reversed by anti-androgens.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

28 citations , October 2011 in “International Journal of Molecular Medicine”

In this study, adenosine was found to stimulate hair follicle growth in vitro by promoting growth factor expression, β-catenin activation, and downstream signaling pathways.

research Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

25 citations , September 2020 in “Molecules”

In this study, quercitrin was reported to promote hair growth and cell viability in cultured human dermal papilla cells by enhancing cellular energy metabolism and growth factor production via MAPK/CREB signaling.

research Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo

25 citations , June 2004 in “Journal of Investigative Dermatology”

This study found that macrophage-stimulating protein (MSP) enhanced hair growth in both human hair follicles cultured in vitro and in mice through the promotion of anagen phase induction.

research Testosterone-stimulated weanlings as an alternative to castrated male rats in the Hershberger anti-androgen assay

25 citations , March 2004 in “Regulatory Toxicology and Pharmacology”

Using testosterone-stimulated weanling rats can effectively replace castrated rats for anti-androgen testing, reducing animal stress.

research Androgens stimulate specific aspects of maternal nest-building and reduce food intake in rabbits

21 citations , February 2003 in “Hormones and Behavior”

This study found that testosterone combined with progesterone stimulated digging behavior in ovariectomized rabbits but also reduced food intake, an effect partially counteracted by progesterone.

research Quercetin stimulates melanogenesis in hair follicle melanocyte of the mouse.

20 citations , December 2013 in “PubMed”

This study found that quercetin increased melanin production in hair follicle tissues from C3H/HeN Jel mice, correlating with higher levels of tyrosinase protein and TRP-2 protein expression.

Is There an Association Between Thyroid Stimulating Hormone Levels and the Four Phenotypes in Polycystic Ovary Syndrome?

research Is there association between thyroid stimulating hormone levels and the four phenotypes in polycystic ovary syndrome?

15 citations , April 2022 in “Ginekologia Polska”

Higher thyroid hormone levels may be linked to certain types of polycystic ovary syndrome.

research Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways

14 citations , September 2018 in “International Journal of Molecular Sciences”

This study found that mackerel-derived fermented fish oil extract and its component DHA promote hair growth by activating anagen pathways in dermal papilla cells.

research Microglia Stimulate Zebrafish Brain Repair Via a Tumor Necrosis Factor-α-Initiated Inflammatory Cascade

9 citations , October 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, researchers found that microglia play a crucial role in neurogenesis and brain regeneration in zebrafish by regulating inflammatory signaling, and their absence impairs these processes.

research Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

8 citations , October 2020 in “International Journal of Molecular Sciences”

This laboratory study found that nonanal, a plant scent compound, may stimulate growth factors and cell proliferation in human hair follicle dermal papilla cells, suggesting a cAMP-mediated mechanism.

research Isolation ofStaphylococcus simulansfrom Dermatitis in a Captive African Pygmy Hedgehog

8 citations , June 2011 in “Journal of Zoo and Wildlife Medicine”

This report documents the first case associating Staphylococcus simulans with dermatitis in pygmy hedgehogs.