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    Glossary Steroidal Antiandrogens

    block male hormone effects to treat hair loss

    Steroidal antiandrogens are a class of medications that block the effects of androgens, which are male sex hormones like testosterone. They are used to treat conditions such as prostate cancer, androgenic alopecia (hair loss), and severe acne by reducing the influence of these hormones on the body. These drugs work by binding to androgen receptors, preventing androgens from exerting their effects.

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    1. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005 · 20 citations
    2. Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen Journal of the American Academy of Dermatology · 2012
    3. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    4. Novel Synthetic Steroid Derivatives: Target Prediction and Biological Evaluation of Antiandrogenic Activity Current Issues in Molecular Biology · 2025
    5. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice British Journal of Dermatology · 1997 · 10 citations
    6. Effects of Prenatal Treatment with Antiandrogens on Luteinizing Hormone Secretion and Sex Steroid Concentrations in Adult Spotted Hyenas, Crocuta crocuta1 Biology of Reproduction · 2002 · 37 citations
    7. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice British Journal of Dermatology · 1997 · 9 citations
    8. Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams European Journal of Medicinal Chemistry · 2010 · 23 citations
    9. Pharmacology of antiandrogens Journal of Steroid Biochemistry · 1986 · 97 citations
    10. Clinical applications of antiandrogens Journal of Steroid Biochemistry · 1988 · 29 citations
    11. Female Antiandrogens Elsevier eBooks · 2017 · 1 citations
    12. Antiandrogens CRC Press eBooks · 2022
    13. Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans Biomedical Chromatography · 2026
    14. Relative binding affinity of novel steroids to androgen receptors in hamster prostate Journal of Enzyme Inhibition and Medicinal Chemistry · 2005 · 5 citations
    15. ANTIANDROGEN AND HORMONAL TREATMENT OF ACNE Dermatologic Clinics · 1996 · 38 citations
    16. The antiandrogenic effect of finasteride against a mutant androgen receptor Cancer Biology & Therapy · 2011 · 20 citations
    17. Distinctive features of steroid hormone metabolism in female patients with androgenic alopecia Vestnik dermatologii i venerologii · 2013
    18. Steroid 5α-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003 · 42 citations
    19. Behandlung mit Antiandrogenen in der Gynäkologie 1977 · 7 citations
    20. Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, <i>InVitro</i>, and <i>In Silico</i> Studies OPAL (Open@LaTrobe) (La Trobe University) · 2025
    21. Antihormonal properties of some new A-homo-B, 19-dinor steroids of the androstane series Steroids · 1992 · 2 citations
    22. Roles of steroid receptors in the lung and COVID-19 Essays in Biochemistry · 2021 · 9 citations
    23. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    24. Proxalutamide Improves Inflammatory, Immunologic, and Thrombogenic Markers in Mild-to-Moderate COVID-19 Males and Females: an Exploratory Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial Early Antiandrogen Therapy (EAT) with Proxalutamide (The EAT-Proxa Biochemical AndroCoV-Trial) medRxiv (Cold Spring Harbor Laboratory) · 2021 · 5 citations
    25. Oral Contraceptives as Anti-Androgenic Treatment of Acne 2002 · 16 citations
    26. Effects of Sex Steroid Deprivation/Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females 2000 · 176 citations
    27. Expression of concern: potential risk for developing severe COVID-19 disease among anabolic steroid users BMJ case reports · 2021 · 21 citations
    28. Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients 2022
    29. Research Brief: Self-Reports of a Constellation of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men American Journal of Men's Health · 2018 · 9 citations
    30. Therapeutic strategies for treating hair loss Drug Discovery Today: Therapeutic Strategies · 2006 · 42 citations