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A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

Ageratum conyzoides L. extract may effectively and safely treat hair loss.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

Finasteride affects the male rat brain by reducing certain protein activation, but these effects may reverse after stopping the drug.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Plant extracts like Avicennia marina, Boehmeria nipononivea, and Camellia sinensis could potentially treat hair loss with fewer side effects than synthetic drugs.

Compounds from Angelica koreana roots, especially osthenol, could be effective for treating conditions like prostate disease and hair loss.

Rats had lasting erectile problems after stopping a certain medication.

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.

The study created a new method to test drugs that affect hormone processing in skin.

Medicines for enlarged prostate may raise the risk of breast growth and tenderness but not breast cancer.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Dutasteride works better than finasteride for hair loss, with both being safe to use.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Plumbago zeylanica extract helps hair growth and reduces a hair loss-related enzyme.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The β-sitosterol hair gel is effective and promising for treating hair loss.

Dutasteride is more effective than Finasteride in reducing prostate size and PSA levels, but both drugs have similar side effects.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Dutasteride is safe and effective for treating hair loss, but may decrease libido.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.