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Mutations in the PTPRQ gene cause significant balance issues in mice due to hair bundle defects in the inner ear.

Ptprq has multiple forms that change during inner ear development.

The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.

Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.

Zebrafish larvae are used to study and find treatments for ear cell damage because they are easier to observe and test than mammals.

Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.

Not having enough or having too much of the protein Grainyhead-like 3 leads to various developmental problems.

Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

Chickens exposed to loud noise can quickly regain hearing mostly due to repair of the tectorial membrane, not just hair cell regeneration.

Scientists found a gene in mice that causes early hearing loss.

Different harmful mutations in the CDH3 gene cause HJMD, but symptoms vary among individuals.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

Some natural compounds can protect fish ear cells from damage by certain antibiotics without affecting the antibiotics' ability to fight infections.

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.

Finasteride causes lasting fertility decrease in rats.

Finasteride changes antioxidant enzyme expression, possibly affecting sperm protection in rats.

Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.

Astrotactin proteins are important for brain and skin development and are linked to several neurodevelopmental disorders.

Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.

Dynamic, light touch is sensed through a common mechanism involving Piezo2 channels in sensory axons.

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

Blocking autophagy increases survival of inner ear hair cells exposed to gentamicin.

Signals from skin cells controlled by Rac proteins help turn certain precursor cells into white fat cells.

Flutamide caused damage to male rat reproductive organs and may affect fertility.

Low Level Laser Therapy may improve noise-induced hearing loss.

Defects in certain proteins cause major heart abnormalities during early development.

PROTO1 and PROTO2 protect against hearing damage.

Frizzled receptors are essential for various body development processes and maintaining certain body functions.