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This study found that transplanting hair follicle bulge-derived stem cells in rats enhanced skin regeneration during expansion by differentiating into several skin-related cells and increasing the expression of growth factors.

This study found that implanting hair-follicle-associated pluripotent stem cell sheets in mice significantly accelerated wound closure and reduced scar formation compared to non-implanted controls.

This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.

This study suggests that using growth factors and ADSC-conditioned medium can enhance keratinocyte viability and migration in epidermal transplantation, potentially improving chronic wound healing rates with a patient-dependent effect.

This review highlights how organoid technology is transforming precision medicine by summarizing its development and applications in modeling diseases, testing drug efficacy, and tailoring patient-specific treatments, despite current challenges in standardization and ethical considerations.

This review discusses the evolving understanding of epithelial stem cells, noting how new models challenge old assumptions and suggesting multiple stem cell populations contribute differently to skin and hair follicle regeneration.

This study found that combining ultrasound with a GelMA hydrogel able to deliver mesenchymal stem cell-derived vesicles significantly improved wound healing in a mouse model by enhancing fibroblast activity, promoting re-epithelialization, and facilitating hair follicle regeneration, highlighting a novel approach to skin regeneration therapy.

This review discusses recent advancements in generating appendage-bearing skin organoids from pluripotent stem cells and their potential applications in dermatological research, but reports no new clinical results.

This study found that SPARC-overexpressing adipose-derived mesenchymal stem cells significantly improved various aspects of skin wound healing in dogs, including re-epithelialization, collagen deposition, and angiogenesis, showing promise for enhancing treatment effectiveness under different physiological and pathological conditions.

This study observed that exosomes from adipose-derived stem cells promoted hair growth by enhancing dermal papilla cell proliferation and activating signaling pathways, suggesting potential for treating immune-mediated alopecia.

This study found that silk fibroin gel induced more pro-regenerative macrophages and hair follicle stem cells, leading to almost scarless skin regeneration compared to alginate gel.

In this study, researchers developed a novel method using ultrasound stimulation and a hydrogel delivery system to enhance the regenerative effects of stem cell-derived extracellular vesicles on severe skin injuries, resulting in improved healing and hair follicle regeneration in a mouse model.

This study found that reconstructed human epidermis from infant skin is more susceptible to UV damage than that from older children, with notable changes in skin cell characteristics during the early years of life.

This study explored a cell-free therapy with mesenchymal stem cell paracrine proteins and PEG hydrogels for deep burn treatment and found that the combination significantly enhanced wound healing, reduced scar formation, and promoted skin appendage regeneration in a rabbit model.

This study found that exosomes derived from antler stem cells significantly enhanced wound healing speed and quality in rats, including better skin regeneration and collagen distribution, outperforming exosomes from bone marrow stem cells, and suggesting potential clinical applications.

This study explored the development of GelMet, an electrospun hybrid nanofiber scaffold made from gelatin and PEG methacrylate, which demonstrated strong mechanical properties and effectively supported cell growth in vitro, suggesting its potential for skin tissue engineering applications.

This source reviews advancements in microneedle-based cosmeceutical delivery, discussing new technologies and highlighting a burgeoning area of research involving microneedling combined with stem cell delivery for anti-aging, without finding measurable changes in skin barrier function or appearance during the study period.

In this review, researchers discuss how mitochondria-targeted biophysical priming of autologous biologics, through methods like photobiomodulation and ultrasound, can potentially enhance skin rejuvenation and wound repair by modulating mitochondrial function in skin cells.

The researchers reported that iPSCs derived from Sendai virus reprogrammed blood cells can mature into functional keratinocytes for up to 60 days, potentially offering new approaches for DEB treatment.

This review discusses the potential of stem cell-based therapies combined with artificial nerve grafts for improving recovery in animal models of severe peripheral nerve injury, highlighting the need for further research on their application to humans.

This study found that dermal stem cells from granulation tissue promoted wound healing and reduced fibrosis in a combined radiation and skin wound mouse model.

This study reviews the role of skin stem cells in aging and explores how organoids, as opposed to traditional methods, can advance research into aging skin and regenerative therapies.

This study reported that exosomes derived from human amniotic mesenchymal stem cells (hAMSC-exo) accelerated hair growth in androgenetic alopecia mice by enhancing signals between hair follicle cells and improving cellular environments, particularly protecting against dihydrotestosterone-induced damage via Wnt/β-catenin signaling.

This study found that adipose stem cell-derived nanovesicles promoted dermal papilla cell proliferation, migration, and anti-apoptotic effects in vitro and enhanced hair follicle cycle progression in mice, primarily through activation of the β-catenin signaling pathway.

In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.

This study found that inhibiting PI3 kinase in epidermal stem cells reduces YBX1 phosphorylation, thereby decreasing cellular senescence and enhancing wound healing and regeneration in adult-derived skin models.

This study found that encapsulating hADSCs-derived exosomes in PF-127 hydrogel improved wound healing in mice, suggesting a promising approach for enhancing skin repair.

This study reports that hair follicle-derived mesenchymal stem cells significantly reduced hair loss and inflammation in alopecia areata models, suggesting a potential therapeutic approach.

This study reported the successful isolation of epithelial stem cells from mouse embryonic skin using a simple culture method, with the cells showing the potential to differentiate into multiple cell types.

This review discusses the advancements and challenges in developing in vitro human skin models incorporating components like vasculature for drug testing and disease research, but reports no new clinical results.