71 citations
,
January 2019 in “International journal of biological sciences” This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.
41 citations
,
July 2012 in “Stem Cells and Development” This study found that low-dose UVB radiation enhances the survival, migration, and hair growth-promoting capacity of adipose-derived stem cells in mice through the generation of reactive oxygen species.
17 citations
,
December 2013 in “PLoS ONE” This study found that the postnatal thymus contains a population of mesenchymal stem cells that may help maintain functional thymic microenvironments.
12 citations
,
December 2019 in “International Journal of Molecular Medicine” This study found that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) significantly prevented hair loss induced by dexamethasone in a mouse model and enhanced cell proliferation in human hair follicle cells, suggesting a protective effect against stress-related hair loss.
3 citations
,
May 2022 in “Oncogene” This study revealed that Vav2 and Vav3 play roles in regulating hair follicle bulge stem cells in normal conditions and cancer stem cell activation and remodeling in mice.
May 2023 in “Research Square (Research Square)” This study found that the natural product Shi-Bi-Man significantly promoted hair regeneration in cynomolgus monkeys, increasing hair follicle number and activation by boosting specific protein markers and interactions in Laminin-related pathways.
182 citations
,
June 2017 in “Biomaterials” This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.
January 2026 in “Open Life Sciences” This study found that exosomes derived from human amniotic mesenchymal stem cells enhanced stem cell proliferation and structural restoration in irradiated salivary glands of rats, with significant improvements observed by day 7, suggesting activation of the Wnt signaling pathway.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study demonstrated that disrupting EGFR signaling in mice leads to immune sensitivity compromising the hair follicle's protective environment, but JAK1/2 inhibition can restore this immune privilege and stimulate hair growth, suggesting a potential therapy for scarring hair loss diseases like cicatricial alopecia.
37 citations
,
April 2017 in “npj Regenerative Medicine” This study found that platelet-derived growth factor signaling is crucial for maintaining the hair follicle dermal stem cell pool and supporting their regenerative capacity.
22 citations
,
November 2017 in “Scientific Reports” This study found that, despite a major depletion of SOX2-expressing stem cells in the pituitary, there was no effect on endocrine cell homeostasis or response to certain stressors in adult mice.
44 citations
,
October 2017 in “Scientific Reports” This study found that far-infrared radiation preconditioning significantly enhanced the proliferation, survival, and migration of bone marrow-derived stem cells in vitro, indicating potential therapeutic benefits for cardiac ischemia treatment.
2 citations
,
June 2016 in “Journal of Korean Medicine” This study found that low concentrations of Asiasarum heterotropoides extract may enhance proliferation of human mesenchymal stem cells from periodontal tissue without affecting cell morphology.
April 2017 in “Journal of Investigative Dermatology” This study found that anagen hair follicles can quickly regenerate after radiation damage by forming new progenitor cells outside the bulge, bypassing the need for telogen entry.
14 citations
,
March 2020 in “Cold Spring Harbor Perspectives in Biology” This review discusses the flexibility and diversity of tissue stem cell systems, particularly focusing on the motility and ligand distribution of spermatogenic stem cells, without presenting new experimental results.
This study discovered that in *Drosophila*, knockdown of specific storage proteins in adipocytes decreased germline stem cell maintenance, implicating a role for these proteins in adult tissue regulation.
15 citations
,
February 2009 in “Cell Stem Cell” This study found that hair germ cells, derived from bulge stem cells, respond faster to dermal papilla signals and have limited proliferation compared to bulge cells during hair regeneration.
13 citations
,
September 2021 in “Frontiers in Cell and Developmental Biology” This study found that suspension culture was more effective than hydrogel-based systems for maintaining spheroid morphology and differentiation of human iPSC-derived definitive endoderm cells.
116 citations
,
August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
May 2026 in “Science Advances” This research observed that translation initiation shifts from cap-dependent to IRES-mediated pathways varied across tissues and cell types under stress and differentiation conditions in mice, with low IRES/Cap ratios signaling high stemness and potential multipotency, mediated by the RNA processing protein PTBP1.
13 citations
,
January 2022 in “Stem cell reviews and reports” This study found that using cultured mesenchymal stem cells from mouse whisker hair follicle outer root sheath in wound healing reduced inflammation, accelerated closure, and resulted in less hypertrophic scarring in mice.
The systematic review reported promising outcomes for stem cell-enriched treatments in aesthetic medicine, such as improved skin rejuvenation, hair restoration, and scar revision. However, challenges like protocol variability and regulatory issues must be addressed to ensure effective and safe clinical applications.
84 citations
,
January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology” This article reviews recent advancements in understanding skin stem cells and their roles in maintaining epidermal homeostasis and repairing wounds, without presenting new experimental findings.
91 citations
,
December 2010 in “Stem Cells” This study found that Wnt signaling regulates the symmetric division of adult neural stem cells, increasing their numbers during subependymal regeneration, stroke response, and colony formation.
83 citations
,
January 2015 in “World Journal of Stem Cells” This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.
10 citations
,
January 2013 in “Stem Cells and Development” This study suggests that dermal stem/progenitor cells can be enriched by intracellular granularity and display high proliferation and differentiation potential in vitro, distinguishing them from other fibroblasts and progenitors.
9 citations
,
August 2015 in “Tissue Engineering and Regenerative Medicine” In this study, human dermal stem/progenitor cell-derived conditioned medium was found to promote hair regrowth in mice, possibly through effects on the Wnt/β-catenin pathway.
9 citations
,
March 2011 in “Current Pharmaceutical Biotechnology” This review discusses current stem cell technologies, their potential therapeutic uses, and imaging techniques for tracking transplanted cells, without reporting new experimental results.
8 citations
,
January 2014 in “Journal of Stem Cell Research & Therapy” This review discusses advancements in stem cell therapy for cutaneous radiation syndrome, highlighting the potential of various stem cell sources to improve wound healing and reduce symptoms, but reports no new clinical results.
7 citations
,
March 2025 in “Free Radical Biology and Medicine” This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.