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This review summarizes recent progress in human hair follicle bulge cell research, particularly the characterization and isolation of these stem cells, but reports no new experimental results.

This study found that exosomes from hair follicle mesenchymal stem cells overexpressing lncRNA H19 promoted diabetic skin wound healing by enhancing cell proliferation, migration, and reducing pyroptosis.

In this study, researchers found that CD4 is expressed on murine K5⁺ keratinocytes, and its expression is crucial for maintaining epidermal stem cell balance and wound repair capacity, particularly during aging.

This study found that SMAD2 overexpression in human hair follicle stem cells promoted differentiation and apoptosis while inhibiting proliferation, and Smurf2 upregulation limited mouse wound healing by suppressing the SMAD2/NANOG/DNMT1 axis.

This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.

This study provides a comprehensive platform to explore stem cell interactions regulating hair follicle growth, revealing key signaling pathways in epithelial-mesenchymal interactions using advanced RNA sequencing and transgenic reporters.

This study found that in mouse skin, the activation of stem/progenitor cells is synchronized across different niches during growth, with the glutamate transporter SLC1A3 playing a crucial role in this process.

This study shows that macrophage-induced TNF signaling can activate hair follicle stem cells and promote new hair follicle formation after wounding by regulating AKT/β-catenin pathways.

This study found that skin-derived precursor cells in mice can originate from both neural crest and somite lineages but show functional similarities regardless of their developmental origins.

This review examines beta-catenin's role in stem cell renewal, lineage selection, and tumor formation in the epidermis and reports no new experimental findings.

This study explored the complex roles of niche cells in regulating hair follicle stem cells, identifying specific cell functions such as signaling, sensing, and relaying messages, which could provide insights into treating hair loss conditions like androgenetic alopecia and alopecia areata.

This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.

This study found that lymphatic vessels in mice are important for hair follicle development and organization, as their depletion blocks hair growth.

This review explores the novel roles of white adipose tissue in tissue homeostasis and regeneration, emphasizing its impact on epithelial, muscle, and immune tissues, and reports no new clinical results.

This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.

This study found that injury affects the behavior of hair follicle dermal stem cells, steering them towards recruitment into the dermal papilla, a shift influenced by the hair cycle stage.

This study found that mammary resident macrophages play a key role in mammary tissue development by influencing cell division and maintaining mammary stem cell activity through the TNF-α-Cdk1/Cyclin B1 signaling pathway, highlighting their importance in the mammary stem cell niche.

This study found that conditioned media from dental pulp stem cells stimulated significantly faster hair growth in mice, suggesting potential as a treatment for alopecia.

This article reviews the development and use of induced pluripotent stem cell models and artificial organoids for studying neurodevelopmental disorders, but it reports no new clinical findings.

The researchers reported that conditioned media from deer antler mesenchymal stem cells may enhance hair and skin regeneration by modulating cellular responses through secretory vesicles.

This review discusses the role of various genetic regulators in maintaining human mesenchymal stem cell stemness and highlights strategies for ex-vivo expansion, but reports no new clinical findings.

This study found that hair follicle stem cells are multipotent and can enhance nerve regeneration and function in mice, showing potential as an accessible source for treating peripheral nerve injuries.

In this review, researchers examined how needle gauge and length impact the viability of human stem cells during injections, emphasizing the balance between minimizing tissue trauma and preserving cell viability to optimize clinical protocols.

This review highlights that exosomes from adipose-derived stem cells, particularly those enriched with circ-Ash1l, can inhibit ferroptosis and reduce UVB-induced skin aging by delivering GPX4-promoting signals to damaged cells, thus offering a potential regenerative therapy for photoaged skin.

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

This study reported that stem cells derived from semi-solid bone marrow improved the healing of diabetic incision wounds in rats by increasing epidermal thickness and blood vessel growth, and reducing hair follicle destruction, cellular penetration, diffuse fibrosis, and necrosis compared to control groups.

This study highlights that human hair follicle dermal papilla cells and glypicans play crucial roles in regulating hair follicle stem cell differentiation.

This study found that mammary resident macrophages regulate mammary epithelium cell division and development, with implications for maintaining mammary stem cell activity and homeostasis.

In June 2019, the stem cell research field saw major progress, including new clinical trials, FDA approvals, and industry collaborations.

This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.