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The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Stem cell technologies and regenerative medicine, including platelet-rich plasma, show promise for hair restoration in treating hair loss, but more research is needed.

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.

Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

The document concludes that using stem cells to regenerate hair follicles could be a promising treatment for hair loss, but there are still challenges to overcome before it can be used clinically.

Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

The tumor suppressor BRCA2 helps in cell division by bringing key proteins to the area where cells split.

Advanced therapies like gene, cell, and tissue engineering show promise for hair regrowth in alopecia, but their safety and effectiveness need more verification.

Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.

Skin stem cells can help improve skin repair and regeneration.

The exact identity of skin stem cells and how skin cells differentiate is not fully known.

Some skin tumors may start from hair follicle stem cells.

Both human platelet lysate and minoxidil can promote hair growth, but they affect different genes and cell survival rates.

Stem cells can help other stem cells by producing supportive factors.