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The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Minoxidil is better for female hair loss without hormonal issues, cyproterone acetate for those with; people with treated congenital heart disease have lower life quality; personality differs in types of infertility; oral terbinafine is best for toenail fungus; bladder training reduces incontinence; nurse clinics help with heart disease; weight loss improves body composition and liver disease; computer training cuts drug errors.

Women with PCOS have more severe liver disease.

A leukemia patient showed skin peeling similar to kwashiorkor, a severe protein deficiency.

SCD1 is crucial for skin health and overall energy balance.

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

A diabetic cat with another gland issue got better after treatment with cabergoline, no longer needing insulin.

Understanding Polycystic Ovary Syndrome (PCOS) and its causes can lead to effective treatments.

Finasteride and dutasteride may cause metabolic issues like liver disease and diabetes.

The document concludes that doctors should thoroughly check postmenopausal women with sudden increased male traits for rare conditions like androgen-producing endometrial cancer.

Pembrolizumab can cause serious liver issues, requiring close monitoring and early treatment.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

GLP-1 receptor agonists, like Dulaglutide, Liraglutide, and Semaglutide, have potential benefits beyond the pancreas, including neuroprotection, pain suppression, cardiovascular protection, obesity management, and cancer treatment, but there are concerns about pancreatitis and pancreatic cancer risks.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

New therapies are being developed that target integrin pathways to treat various diseases.

Blocking the ATX-LPA pathway may improve insulin sensitivity and mitochondrial function in obesity.

Methotrexate is a promising and safe treatment for severe alopecia areata, with better results when combined with corticosteroids.

THSG from a Chinese plant helps with aging and related diseases.

SIRT7 protein is crucial for starting hair growth in mice.

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

Sirtuin 1 could be a potential drug target for treating hypertrophic scars.

Vitamin A toxicity can cause severe health issues and may require a liver transplant if other treatments fail.

Adipokines affect skin health and could be targeted for treating skin diseases.

Adults should not consume more than 255 micrograms of selenium per day to avoid risk of hair loss and other side effects.

The Polish medical societies have redefined metabolic syndrome and recommend lifestyle changes, certain medications, and possibly bariatric surgery for treatment. They also discuss managing related health conditions.

Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.

Hormone therapy for prostate cancer can increase heart risks, especially in men with heart conditions.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

Using a drug to activate bone marrow stem cells can help the liver regenerate and function better after major surgery in rats.