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Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

Methylation in specific gene region causes finasteride resistance in some BPH patients.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The study suggests that analyzing DNA can help treat hair loss, but more research is needed.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Plumbago zeylanica extract helps hair growth and reduces a hair loss-related enzyme.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The girl's unexpected pubic hair growth led to a diagnosis different from complete androgen insensitivity syndrome.

Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

The conclusion is that more research is needed to understand if the drug finasteride causes Post-Finasteride Syndrome or if it's due to individual genetic makeup.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.

Androgenetic alopecia is influenced by various factors and can be treated with medications, procedures, and non-drug methods.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

A new hair loss treatment uses tiny needles to deliver a drug-loaded lipid carrier, promoting hair growth more effectively than current treatments.

Chitrak is a medicinal plant with health benefits like fighting microbes, reducing inflammation, and promoting hair growth, but it can be toxic and needs more research.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Light therapy might help treat hereditary hair loss by improving hair follicle growth in lab cultures.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Dutasteride is more efficient than finasteride, but individual results vary.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Finasteride's sexual side effects not caused by androgen deficiency or SRD5A inhibition.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.