Response to Letter: Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss

This document is a response to a letter regarding a study on men who reported persistent sexual symptoms after using finasteride for hair loss. The authors of the study defend their conclusion that the symptoms are unlikely to be due to androgen deficiency or persistent inhibition of SRD5A activity. They also discuss the findings of a functional magnetic resonance imaging (fMRI) study on the neurobiology underlying sexual function and dysfunction, which revealed commonalities in the regions identified in different studies. The authors agree that a possible causal relationship will likely only be demonstrated in a well-designed large prospective observational study.