Androgenetic Alopecia: Update on Etiology, Pathophysiology, Diagnosis, and Treatment

    March 2024 in “ International journal of pharmaceutical sciences and drug research ”
    Cherishma Raju P, Babiker Bashir Haroun Baraka, B. Appa Rao, Chetana S Karadi, Supriya Srinivasa Gowda, Ramesh Kumar
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    TLDR Androgenetic alopecia is influenced by various factors and can be treated with medications, procedures, and non-drug methods.
    Androgenetic alopecia (AGA), also known as patterned hair loss, is influenced by androgens and factors such as age, sex, genetics, smoking, and alcohol. If untreated, it can lead to psychological issues like stress, anxiety, and depression. Diagnosis involves clinical examination, hormonal tests, trichoscopy, and scalp biopsy. Treatments include non-pharmacologic methods (e.g., wigs, hair-thickening fibers), semi-permanent options (e.g., scalp micro-pigmentation), and USFDA-approved drugs (Minoxidil and Finasteride). Non-USFDA approved treatments include surgical procedures (e.g., hair transplantation), microneedling, light therapy, indigenous medicines, and Platelet-Rich Plasma (PRP). The review aims to provide updated insights into novel therapies and enhance patient knowledge about AGA and its treatments.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community How essential is scalp biopsy when dealing with hair loss?

      in Treatment  6 upvotes 1 year ago
      The user experienced hair loss despite using Fin and Min for 12 years and switched to Dutasteride, RU58841, and Keto scalp serum, but shedding and itch persist. They are considering increasing Dutasteride to 2.5mg and questioning the necessity of a scalp biopsy, with mixed opinions on its usefulness.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  418 upvotes 11 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community DHEA, the culprit behind DUPA ? Read this!

      in Research/Science  19 upvotes 2 years ago
      High DHEA levels may contribute to hair loss by increasing DHT in hair follicles, potentially explaining why finasteride is ineffective for some. Treatments like high-dose dutasteride and RU58841 are suggested, but the underlying cause, such as adrenal issues, should be investigated.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  83 upvotes 2 years ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

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