2 citations
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September 2008 in “Fertility and Sterility” This study observed that adult offspring of sperm donation generally feel positive about their conception method and believe identifying information about donors should be accessible.
3 citations
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April 2012 in “Fertility and Sterility” This article reviews the commonality of androgenic alopecia in men over 30 and the use of finasteride, without reporting new research findings.
2 citations
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January 2015 in “Springer eBooks” Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.
October 1988 in “Pediatric research” In this study, researchers observed that the sequence of maturity markers in normal boys showed specific time lags, with some markers appearing before and others after spermarche.
October 2020 in “Journal of Pakistan Association of Dermatology” This analysis of seven studies explored the impact of finasteride (1mg/day for androgenic alopecia) on sperm concentration, finding that in most studies, sperm concentration increased after stopping treatment, but the largest study showed no change during or after treatment.
2 citations
,
September 2017 in “Archives of Medical Science” The researchers reported that finasteride treatment in male rats may lead to changes in antioxidant enzyme activity in their offspring's epididymis, potentially affecting sperm maturation.
1 citations
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September 2023 in “Journal of Education Health and Sport” This study provides a comprehensive analysis of anabolic-androgenic steroids, reporting that their use enhances muscle mass but is associated with significant health issues including cardiac muscle hypertrophy, liver disease, and changes in gender characteristics, emphasizing the need for patient awareness of these risks.
June 2026 in “The Journal of Sexual Medicine” This study determined that men taking finasteride 1 mg/day exhibited significantly reduced sperm production and morphology compared to controls, although there were no notable changes in hormonal, sexual, or psychological function.
June 2026 in “British Journal of Dermatology” This study reviewed human evidence on the effects of 5α-reductase inhibitors, finasteride and dutasteride, on semen parameters and gonadotrophins, finding finasteride causes mild, reversible changes, while dutasteride may lead to more pronounced and potentially less reversible impacts, suggesting caution for those planning to conceive.
33 citations
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April 2015 in “Current Opinion in Endocrinology, Diabetes and Obesity” This review discusses the potential persistent adverse effects associated with 5α reductase inhibitor treatment for androgenetic alopecia but provides no new clinical results; it emphasizes the importance of discussing these risks with patients.
January 2018 in “日本薬理学会年会要旨集 =” This study reports that in young male patients with finasteride-associated infertility, semen parameters appear reversible after discontinuing the medication.
May 2025 in “Gynecological Endocrinology” This study observed that men with a family history of PCOS had lower median sperm concentration and higher rates of alopecia and gynecomastia compared to those without such a family history.
18 citations
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June 2009 in “Journal of Molecular Endocrinology” This study found that exposure to finasteride impaired spermatogenesis in male Xenopus laevis by affecting sex-specific feedback mechanisms in the hypothalamus–pituitary–gonad axis.
May 2023 in “Frontiers in Veterinary Science” This collection of articles explores advancements in reproductive technologies for domestic dogs and cats, highlighting improvements like finasteride treatment for BPH in dogs and a rapid freezing method for cat sperm that enhance fertility preservation and genetic resource banking.
This study found that chronic administration of finasteride in rats led to significant alterations in the epididymis and compromised sperm quality, effects that persisted even after 30 days of treatment cessation.
April 2011 in “The FASEB Journal” This research found that prolonged doses of Amlodipine at 5mg/kg BW or higher impaired fertility indicators in adult male rats, affecting sperm morphology, count, and motility.
34 citations
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January 2004 in “Revista do Hospital das Clínicas” The authors reported that young men with infertility-related conditions experienced improved seminal quality after stopping finasteride, suggesting potential adverse effects on fertility during treatment.
10 citations
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February 2020 in “Endocrine” This study found that finasteride treatment in males with androgenetic alopecia was linked to significant changes in sperm parameters and increased testosterone levels, but no sexual dysfunction was observed, and sperm parameters returned to baseline after treatment stopped.
1 citations
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July 2021 in “Current Issues in Molecular Biology” This study found that finasteride treatment of male rats led to changes in their male offspring's testicular gene expression, potentially affecting sperm function in response to odorant-like signals.
April 2026 in “Research Square” This study found that COVID-19 infection disrupts spermatogenesis, alters testicular cell populations, and may impact male fertility by causing long-term changes in testicular function and reduced sperm quality, as observed even in patients who have recovered from the acute phase of the infection.
2 citations
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October 2000 in “The Journal of Urology” Finasteride daily doesn't affect sperm production or semen in young men.
26 citations
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September 2005 in “Pharmacology Biochemistry and Behavior” This study found that inhibiting the 5alpha-reductase 2 pathway in male rats affects brain sexual differentiation and leads to reproductive changes, including increased pre-implantation loss despite unchanged copulatory potential.
1 citations
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May 2023 in “Fertility and sterility” In this cohort study of young Danish men, self-reported older age at voice break was linked to certain reproductive hormone changes that suggest reduced male fecundity, but associations with semen characteristics and testicular volume were not statistically significant.
This review reports that 5-alpha reductase inhibitors, used to treat androgenic alopecia, may adversely affect sperm count, sexual function, and hormones in a subset of patients.
December 2025 in “Microscopy and Microanalysis” This study found that administering lycopene to rats provided significant protection against the testicular damage caused by finasteride, as indicated by improved sperm parameters, and reduced oxidative stress and apoptosis markers.
February 2026 in “Andrology” This study highlights the need for a comprehensive andrological assessment at diagnosis, including semen and hormonal analysis, to guide fertility preservation strategies, and found that post-orchidectomy semen samples showed improved DNA integrity for assisted reproductive technologies.
195 citations
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February 2007 in “The Journal of Clinical Endocrinology and Metabolism” In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.
4 citations
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October 2000 in “Contraception” This study found that a regimen combining cyproterone acetate and testosterone buciclate induced reversible azoospermia in bonnet monkeys, highlighting its potential as an effective male contraceptive.
May 2025 in “Veterinary Medicine and Science” In this study, oral melatonin given to male Pomeranian dogs with Alopecia X improved semen quality and testicular blood flow in a dose-dependent manner, but altered hormonal balance, indicating complex effects that require further investigation for long-term implications.
May 2025 in “Ecology and Evolution” This study reports the draft genome sequence of the endangered Indus River dolphin and suggests potential genetic adaptations to freshwater environments, including specialized skin features and immune adaptations, while also highlighting historical and human-induced factors contributing to its low genetic diversity.