Anti-Fertility Effects of Amlodipine in Adult Male Wistar Rats

The study investigated the anti-fertility effects of Amlodipine, a calcium channel blocker, on adult male Wistar rats. Thirty-three rats were divided into seven groups, with control groups receiving saline and experimental groups receiving varying doses of Amlodipine (5-40 mg/kg BW) for 56-65 days. The results showed that Amlodipine caused reduced body weight, hair loss, and loss of locomotion and balance in a dose-dependent manner. Although testosterone levels remained unaffected, there were significant dose-dependent anomalies in sperm morphology, including sperms with no head and double tail, along with reduced sperm count and motility. Histological analysis revealed changes such as scanty seminiferous tubules and reduced interstitial cells. The study concluded that Amlodipine impaired fertility in male rats at doses of 5 mg/kg BW or higher.