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In this case report, a three-generation family with Gorlin-Goltz syndrome showed a heterozygous PTCH1 splice-donor variant associated with the disease, and two affected relatives benefited from individualized, side-effect-guided dosing of the drug sonidegib, experiencing regression of basal cell carcinoma lesions.

This study observed that sonidegib led to a meaningful clinical response in a real-world Chinese cohort with locally advanced basal cell carcinoma, although pathological biopsy remains essential to confirm tumor clearance due to false positives in noninvasive assessments.

This study found that while pulverization yielded slightly higher hair cortisol extraction, the significant interindividual differences observed suggest that any of the methods could be used effectively.

This report presented a case of a patient with basal cell carcinoma and systemic lupus erythematosus who was treated successfully with sonidegib, showing positive outcomes without worsening lupus activity, despite lacking documented clinical use of sonidegib in such patients.

This study formulated nanostructured lipid carriers with curcumin, using specific surfactants, to enhance its stability and bioavailability for more effective androgenetic alopecia treatment.

The study found that sonication washing of hair roots with fewer than 50 visible nuclei could reduce the number of nuclei available for DNA extraction and STR typing, suggesting that for laboratories focused on nuDNA analysis, a gentler washing method might be adequate.

In this study, 45 patients with advanced basal cell carcinoma treated with the medication sonidegib experienced a 24% incidence of alopecia, with detailed trichoscopic and LC-OCT examination revealing specific hair changes, suggesting LC-OCT might help identify early signs of alopecia from sonidegib use.

In this quasi-experimental study, researchers explored the optimal formulation of a nanoemulsion containing candlenut ethanol extract, finding that specific combinations of tween 80, span 80, and sonication time affected its physical properties and stability, although further activity testing is needed.

This study found that lentivirus-mediated overexpression of Sonic hedgehog significantly increased hair follicle stem cell proliferation and promoted hair follicle regeneration, with higher effects in non-alopecia areas.

In this study, researchers observed that acne and hirsutism were the most common cutaneous manifestations in Indian women with PCOS, but these did not correlate with the number of ovarian follicles.

In this study, Nε-(carboxymethyl) lysine was found to weaken hair follicle morphogenesis and inhibit essential cell activities in a model simulating accumulated glycation.

In this study, injecting Nε-(carboxymethyl) lysine into skin tissue weakened hair shaft and follicle formation, likely by inhibiting cell proliferation and migration needed for hair follicle morphogenesis.

This study found that Sonic hedgehog signaling is crucial for Merkel cell development around hair follicles in mice, with Polycomb repressive complex 2 loss causing ectopic Merkel cells across all hair types.

This study suggests that Sonic hedgehog from hair follicles may support the proliferation of dentate neural stem cells in mice through transport by platelets during the perinatal period.

This study found that Sonirid Duo, a combination of tamsulosin and finasteride, significantly improved symptoms and quality of life in patients with BPH over 12 months.

This study identified interactions between EGF signaling and the GLI proteins in basal cell carcinoma that may contribute to the limited metastasis seen in this skin cancer.

This study found that Shh and Dhh overexpression in mouse basal cells led to similar epidermal and limb phenotypes, suggesting Dhh functions similarly to Shh in skin, unlike Ihh.

This study found that sonicated platelet-rich plasma was more effective than calcium chloride-induced platelet-rich plasma in activating hair follicle stem cells and promoting hair follicle regeneration in mice.

This study found that the currently established ultrasound cut-off values for diagnosing PCOS are not applicable to Indian women, suggesting that region-specific criteria improve diagnostic accuracy.

This study suggests the mechanical effect of injecting a solution is more important than the solution's nature in treating atrophic acne scars, with UBM sonography proposed for objective assessment.

This review summarizes the bioactive compounds and pharmacological functions of Cynomorium songaricum Rupr., emphasizing its potential in developing health-related products, and notes that further research is needed.

In this study from Bangladesh Medical University, researchers found strong correlations between symptoms such as oligomenorrhea and amenorrhea with bilateral polycystic ovarian morphology in women with PCOS, highlighting the link between clinical symptoms and ultrasound findings in predicting the severity of the condition.

This study found that dauricine, a natural compound, may inhibit cell growth and enhance apoptosis in neuroblastoma and glioblastoma by blocking the Oct4/Shh pathway and AKT/β-catenin signaling.

This study reported that recombinant sonic hedgehog proteins can promote hair growth by activating hair-related genes and signaling pathways, suggesting potential as a therapeutic agent in mice.

This study found that carboxytherapy significantly improved skin wrinkles, laxity, and pigmentation among 28 patients with skin aging on the abdomen, accompanied by increased epidermis and dermis thickness and no significant side effects.

Mother and son diagnosed with a rare genetic hair loss condition with no effective treatment.

This study found that the Sonowal Kachari tribe in Assam, India, utilizes 39 plant species for medicinal purposes, with leaves being the most commonly used part, highlighting the tribe's substantial traditional knowledge of herbal medicine.

This study developed an ultrahigh-power sonicator to improve protein extraction from hair shafts, followed by advanced proteomic analysis, identifying 239 differentially expressed proteins in fetal growth restriction cases compared to healthy controls, which were validated as potential biomarkers for perinatal diagnostics.