Effect of Sonicator Probe on the Formulation of Nanostructured Lipid Carriers for Curcumin Using Solid Lipid Precirol
TLDR Nanostructured Lipid Carriers can improve curcumin's effectiveness for treating hair loss.
The study investigates the formulation of Nanostructured Lipid Carriers (NLC) for delivering curcumin to treat Androgenetic Alopecia (AGA), a common form of hair loss influenced by dihydrotestosterone (DHT). Curcumin, known for its antiandrogenic properties, can inhibit steroid 5-alpha reductase, reducing excess DHT. However, curcumin's poor water solubility and low bioavailability limit its effectiveness. The research aimed to enhance curcumin's stability and bioavailability using NLCs formulated with Glyceryl palmitostearate, Capric triglyceride, and surfactants PEG-40 hydrogenated castor oil and Decyl Glucoside. The NLCs were prepared using high shear homogenization/sonicator probe, resulting in particles <400 nm, zeta potential > ±20 mV, and encapsulation efficiency >80%. These characteristics suggest that NLCs could improve curcumin's therapeutic efficacy for AGA.
