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This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.

This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.

This study suggests that deregulation of sonic and desert hedgehog signaling in mouse skin can lead to altered epidermal stem cell activity and lesions similar to human basal cell carcinoma, indicating these cancers may originate outside the stem cell population.

This study found that Sonic Hedgehog secreted by hair follicle transit-amplifying cells is essential for dermal adipogenesis and hair follicle growth by acting on adipocyte precursors.

This study found that ZDHHC13 deficiency in mice is associated with abnormal liver function, lipid metabolism issues, and impaired mitochondrial function, highlighting ZDHHC13's regulatory role in liver metabolism.

This study in mice found that overexpressing Sonic Hedgehog in basal cells caused skin anomalies and a lack of certain hair fibers, underscoring its key role in hair follicle development.

This study found that impaired autophagy plays a role in sonic hedgehog pathway-induced endometrial fibrosis, suggesting it as a potential target for treating intrauterine adhesion.

This study found that enhanced expression of the Sonic hedgehog gene via an adenovirus vector accelerated hair regrowth in mice with chemotherapy-induced alopecia.

This study found that certain chemotherapeutic agents, such as cyclophosphamide, disrupt feather formation and induce hair loss in mice by inhibiting cell proliferation through sonic hedgehog gene downregulation.

This review reports that sonidegib and vismodegib, two Hedgehog inhibitors used for treating advanced basal cell carcinoma, have similar efficacy and safety profiles, but differ in pharmacokinetics, with sonidegib achieving peak concentration more rapidly and reaching steady state later than vismodegib.

This review examines the role of Sonic Hedgehog signaling in the maintenance and repair of skin and lung barriers, and its influence on inflammation and atopic diseases; it presents no new clinical findings.

In this study, transiently activating the sonic hedgehog signaling pathway in chickens transformed reticulate scales on the feet into feathers comparable to body feathers, without ongoing treatment, suggesting this pathway affects the diversity of bird skin appendages.

This report describes the sonographic characteristics of a proliferating trichilemmal tumor in the subungual region, identifying it as a heterogeneous mass with echogenic foci, potentially representing keratin and cholesterol.

In this study, EGCG from green tea promoted mink hair follicle growth and cell proliferation at specific concentrations, potentially through activation of Shh and AKT signaling pathways.

This study reported that Sonic hedgehog signaling is crucial for hair follicle development, with its expression being significantly induced in normal embryonic hair germs but inhibited in certain experimental models.

This study demonstrated that minoxidil-encapsulated PLLGA nanoparticles significantly increased minoxidil delivery to hair follicles compared to a minoxidil aqueous solution in mice.

In this study, brief ultrasound exposure reduced the follicular contribution to hydrocortisone absorption while significantly increasing total skin permeability, likely due to removal of the upper stratum corneum.

This report describes the successful use of sonidegib in treating two cases of locally advanced basal cell carcinoma, leading to remission in both instances, and reducing lesions in a patient with Gorlin syndrome, while noting mild side effects consistent with the drug's known profile.

This study found that Datura metel extracts obtained through supercritical CO2 extraction demonstrated significant biological activity, including antioxidant and anti-inflammatory properties, and effectively promoted wound closure and collagen preservation, comparable to standard treatments, in laboratory experiments.

This study found that the expression of the sonic hedgehog protein is involved in wound healing texture regeneration, inhibiting skin texture after embryonic day 14 and affecting keratinocyte migration and division.

This study found that low-frequency sonophoresis significantly decreased the skin penetration of sodium fluorescein-loaded PEGylated liposomes with D-limonene and affected percutaneous absorption by partially plugging hair follicle orifices.

This study found that activating SHH signaling in EPCs enhances angiogenesis to aid in healing pressure ulcers through the PI3K/AKT/eNOS pathway, indicating SHH signaling as a potential target for treatment.

This study suggests that activating the PPARs/SHH-mitochondrial axis may enhance diabetic wound healing by improving endothelial cell metabolism and angiogenesis, indicating potential for PPAR agonists in treating diabetic foot ulcers.

This study found that downregulation of Sonic hedgehog signaling may promote HPV replication and wart formation by inducing cell cycle arrest in keratinocytes.

This study found that low frequency sonophoresis may reduce percutaneous absorption of sodium fluorescein-loaded liposomes by partially blocking follicular pathways in the skin.

This study reports that hedgehog pathway inhibitors, sonidegib and vismodegib, showed distinct adverse event patterns in real-world data, suggesting the need for further research to confirm these findings.

In this study, the researchers compared subcutaneous fat in the frontal and occipital scalp regions, which are affected and spared in androgenetic alopecia respectively, to better understand the role of subcutaneous fat in the condition's pathogenesis.

This study reviewed various supplements for treating androgenetic alopecia and found that Serenoa repens shows the strongest evidence for use as a single treatment, while ketoconazole may help as an adjunct. Other supplements like zinc, vitamin D, and biotina are not recommended unless deficiencies exist.

This study reported normative ranges for uterine and ovarian dimensions in Indian women aged 18–40, noting correlations with anthropometric and hormonal factors. These findings aim to improve diagnosis and management of reproductive health disorders in this population.

This pilot study found that plasma- and sonophoresis-assisted delivery of an exosome-containing formulation improved hair and scalp metrics over 12 weeks, with short-term safety observed, but controlled trials are needed for confirmation.