Downregulation of Sonic Hedgehog Signaling Induces G2 Arrest in Genital Warts

December 2022 in “ Skin Research and Technology ”

Xiangxi Du, Shan Li, Kun Yang, Yuchun Cao

Sonic hedgehog signaling Patched-1 GLI family zinc finger 1 G2 arrest keratinocytes HPV-DNA G2/M arrest

TLDR Reduced Sonic hedgehog signaling leads to increased HPV replication and wart formation.

This study investigated the role of Sonic hedgehog (SHh) signaling in the formation of genital warts by examining nine male patients with genital warts. It was found that SHh and its downstream molecules, Patched‐1 and GLI family zinc finger 1, were significantly downregulated in wart tissues compared to normal foreskin. This downregulation was associated with an increase in G2-phase cells and a negative correlation with HPV-DNA expression. In vitro experiments showed that reduced SHh signaling induced G2 arrest in keratinocytes. The study concludes that downregulation of SHh signaling promotes HPV replication and wart formation by causing G2/M arrest in keratinocytes.

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