Downregulation of Sonic Hedgehog Signaling Induces G2 Arrest in Genital Warts

December 2022 in “ Skin Research and Technology ”

Xiangxi Du, Shan Li, Kun Yang, Yuchun Cao

Sonic hedgehog signaling Patched-1 GLI family zinc finger 1 G2 arrest keratinocytes HPV-DNA G2/M arrest

TLDR Reduced Sonic hedgehog signaling leads to increased HPV replication and wart formation.

The study examined the Sonic hedgehog (SHh) signaling pathway's role in condyloma acuminatum (CA) warts, caused by HPV6/11, involving 9 male patients. It found that downregulation of the SHh pathway in keratinocytes from genital warts is linked to G2 phase arrest, which may inhibit HPV replication. This suggests that targeting the SHh pathway could be a potential strategy for developing personalized treatments and preventive measures for CA warts. In vitro experiments further supported that silencing SHh expression increases G2 arrest, indicating that restoring SHh activity might reverse this effect and aid in treating and preventing genital warts.

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