Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage

    September 2014 in “ Journal of Investigative Dermatology ”
    Guojiang Xie, Hangwei Wang, Zhipeng Yan … Zhicao Yue
    Studysummary This study found that certain chemotherapeutic agents, such as cyclophosphamide, disrupt feather formation and induce hair loss in mice by inhibiting cell proliferation through sonic hedgehog gene downregulation.
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    Research cited in this study 21

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