Transient Agonism of the Sonic Hedgehog Pathway Triggers a Permanent Transition of Skin Appendage Fate in the Chicken Embryo

    May 2023 in “ Science Advances ”
    Rory L. Cooper, Michel C. Milinkovitch
    Studysummary In this study, transiently activating the sonic hedgehog signaling pathway in chickens transformed reticulate scales on the feet into feathers comparable to body feathers, without ongoing treatment, suggesting this pathway affects the diversity of bird skin appendages.
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    Research cited in this study 4

    1. Feather Arrays Are Patterned by Interacting Signaling and Cell Density Waves PLoS Biology · 2019
    2. Comprehensive Molecular and Cellular Studies Suggest Avian Scutate Scales Are Secondarily Derived from Feathers, and More Distant from Reptilian Scales Scientific Reports · 2018
    3. BMP2 And BMP7 Play Antagonistic Roles In Feather Induction Development · 2008
    4. The Secret Life of the Hair Follicle Trends in genetics · 1992