Sonic Hedgehog Signaling Promotes Angiogenesis of Endothelial Progenitor Cells to Improve Pressure Ulcers Healing by PI3K/AKT/eNOS Signaling

October 2023 in “ Aging ”

Jianhua Wang, Hongyan Zhan, Mingming Wang, Hua Song, Jianhua Sun, Gang Zhao

Sonic hedgehog signaling endothelial progenitor cells PI3K/AKT/eNOS signaling pathway angiogenesis

TLDR Sonic hedgehog signaling helps heal pressure ulcers by improving blood vessel growth.

The study demonstrates that Sonic hedgehog (SHH) signaling enhances the angiogenic properties of endothelial progenitor cells (EPCs), thereby improving the healing of pressure ulcers through the PI3K/AKT/eNOS signaling pathway. This suggests that SHH signaling could be a potential target for treating pressure ulcers.

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