Nε-(Carboxymethyl) Lysine Represses Hair Follicle Formation by Inhibiting Sonic Hedgehog Expression in a NF-κB-Independent Manner

February 2019 in “ International Journal of Dermatology and Clinical Research ”

Ken Tanaka, Kana Mizuno, Chika Natsume, Misaki Takanishi, Y. Shimada, Ryoichi Saito, N Fujita, Takashi Fujita

Nε-(carboxymethyl) lysine advanced glycation end product hair follicle formation Sonic hedgehog dermal papilla cells hair shaft hair follicle morphogenesis tissue morphogenesis NF-κB CML Shh DPC

Studysummary In this study, Nε-(carboxymethyl) lysine was found to weaken hair follicle morphogenesis and inhibit essential cell activities in a model simulating accumulated glycation. Our plain-language summary of this paper — not a Tressless recommendation.

The study explored the impact of Nε-(carboxymethyl) lysine (CML) on hair follicle formation and hair growth, revealing that CML weakened hair follicle formation and inhibited hair shaft growth in mice by suppressing Sonic hedgehog (Shh) expression through a RAGE-mediated, NF-κB-independent pathway. This suppression led to hair growth defects, including thinning hair shafts and miniaturized hair bulbs, without affecting apoptosis. CML also inhibited the migration and proliferation of dermal papilla cells, suggesting that CML accumulation could delay hair follicle formation by affecting both epithelial and mesenchymal cell proliferation. These findings provided insights into the mechanisms of hair growth inhibition related to oxidative stress and protein damage, highlighting potential therapeutic targets for hair loss associated with aging and glycation.

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