October 2023 in “F1000Research” TB lymphadenitis can occur in people with SLE on long-term immunosuppressive therapy.
August 2023 in “Annales de Dermatologie et de Vénéréologie” This review analyzed data from 237 patients across 27 publications to provide an updated overview of non-scarring alopecia (NSA) in lupus erythematosus (LE) patients. It found that diffuse/patchy NSA and lupus hair are strongly associated with systemic LE activity, show subtle signs of inflammation, and typically respond well to SLE therapy without progressing to scarring alopecia. In contrast, NSA associated with dermal cutaneous LE or lupus panniculitis of the scalp is less commonly linked to SLE and responds better to skin-directed therapies. The study suggests that diffuse/patchy NSA and lupus hair may be variations of a single LE-specific entity and calls for prospective studies to further explore this manifestation.
June 2023 in “F1000Research” A young woman with lupus developed tuberculosis due to weakened immunity from her medication, showing the need for better TB screening in such patients.
32 citations,
September 1989 in “Medical Clinics of North America” Skin problems are common in lupus, important for diagnosis, and can be triggered by sunlight.
3 citations,
January 2023 in “Physiological Research” Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
January 2019 in “Elsevier eBooks” Different hair disorders have specific treatments and outcomes, with some resolving on their own and others requiring medication or emotional support.
3 citations,
October 2019 in “JAAD Case Reports” Two patients with lupus had an unusual type of hair loss not typical for the disease but improved with treatment.
3 citations,
January 2013 in “Journal of the European Academy of Dermatology and Venereology” The document suggests that severe hair loss in SLE patients may be an early sign of scalp DLE, treatable with immunosuppressive therapy.
September 2022 in “Health and Medical Journal” Minoxidil and oral antioxidants helped improve hair growth in a patient with hair loss due to lupus.
42 citations,
April 2021 in “Journal of clinical pharmacology” Baricitinib helps treat several diseases, including COVID-19, but has side effects and needs careful monitoring.
2 citations,
September 2022 in “Cytotherapy” Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.
August 2023 in “Rheumatology” Early referral to a pediatric rheumatologist and thorough evaluation are crucial for treating complex overlap syndromes effectively.
1 citations,
September 2022 A 60-year-old patient developed drug-induced lupus erythematosus (DIL) after receiving a combination of monoclonal antibodies against the SARS-CoV-2 surface S-protein. Initially diagnosed with seronegative rheumatoid arthritis, the patient experienced recurring arthritis and was treated with various medications. After mild COVID-19 and subsequent monoclonal antibody therapy, the patient developed a urticaria-like rash and arthritis. Laboratory tests indicated systemic lupus erythematosus (SLE), but the diagnosis was considered DIL due to the timing of symptoms and lack of visceral organ involvement. Treatment led to a reduction in symptoms. This case highlights the challenge of distinguishing DIL from SLE and the need for careful patient monitoring.
5 citations,
July 1991 in “Irish Journal of Medical Science (1971 -)” Immunosuppressive therapy helps manage autoimmune diseases but carries risks like infection and potential for malignancy.
12 citations,
December 2018 in “International Journal of Women's Dermatology” Hormone therapy in transgender women can affect hair growth and acne, and there are specific skin issues related to gender-affirming surgery, but more research is needed on their dermatological health.
6 citations,
April 2020 in “Cureus” A woman with both TLE and SLE improved with hydroxychloroquine treatment.
18 citations,
March 2004 in “Clinics in Dermatology” Lupus can cause hair loss and nail changes, with treatments available for both.
16 citations,
July 2002 in “Australasian Journal of Dermatology” A woman with lupus experienced skin death due to a blood clotting disorder after stopping a blood thinner, which healed with treatment.
January 2023 in “Annals of African Medicine” This case report discusses the treatment of aggressive periodontitis in a 24-year-old female patient with systemic lupus erythematosus (SLE). The patient exhibited symptoms such as hair loss, weakness, leg edema, and arthralgia. Diagnosed with SLE a year prior, she presented with generalized widening of spaces between her teeth. The treatment involved nonsurgical periodontal therapy, flap surgery, debridement, root conditioning with tetracycline, and the placement of bovine osseous xenograft in areas of angular bone loss. Follow-ups at 6 months and 8 years showed satisfactory clinical and radiographic outcomes, supporting the use of xenograft in treating aggressive periodontitis in patients with SLE.
November 2021 in “Frontiers in medicine” A patient with both bullous lichen planus and systemic lupus erythematosus showed improvement with treatment.
May 2023 in “Karnataka Pediatric Journal” Systemic lupus erythematosus (SLE) is a rare autoimmune disease in children, and acute pancreatitis as its initial manifestation is even more uncommon. An 8-year-old girl presented with abdominal pain, nausea, vomiting, fever, alopecia, oral ulceration, and glossitis. Elevated serum amylase and lipase levels indicated acute pancreatitis, while other tests confirmed SLE. Treatment with glucocorticoids and immunosuppressive therapy significantly improved her condition, and she is now stable with regular follow-ups.
15 citations,
January 2014 in “Anais Brasileiros de Dermatologia” Lupus treatment requires a combination of drugs and therapies, with research needed for new options.
6 citations,
April 2021 in “Frontiers in Immunology” A patient with lupus and long-term hair loss saw significant hair regrowth after using the drug tofacitinib.
6 citations,
May 2006 in “Lupus” People with lupus and rheumatoid arthritis have thinner hair than healthy people.
August 2024 in “Intisari Sains Medis” A 17-year-old girl with systemic lupus erythematosus (SLE) presented with a seizure and subsequent loss of voice, alongside symptoms like severe hair loss, fever, and various hematological abnormalities. MRI showed brain atrophy, and echocardiography revealed mild carditis and pericardial effusion. Immunological tests confirmed SLE. Fiberoptic laryngoscopy identified bilateral vocal cord palsy due to SLE. Treatment with high-dose methylprednisolone, cyclophosphamide, and speech therapy led to gradual improvement in her speech. Continuous monitoring is necessary for complete resolution of the vocal cord palsy.
A 29-year-old woman was diagnosed with ANA-negative Systemic Lupus Erythematosus (SLE) presenting with segmental hyalinizing vasculitis and valvular heart disease. Despite the absence of antinuclear antibodies, her symptoms and clinical findings, including painful skin ulcers, joint pain, fever, and heart issues, met the criteria for SLE. Treatment with hydroxychloroquine, methylprednisolone, and desoximethasone cream led to significant clinical improvement and complete resolution of skin ulcers after 6 months, highlighting the importance of early recognition and aggressive therapy in this rare SLE subset.
A man with painful ear plaques was diagnosed with discoid lupus and treated with medications and lifestyle changes.
4 citations,
June 2013 in “The Journal of Rheumatology” The document concludes that various findings in rheumatology offer insights into disease severity, treatment responses, and potential risks in medication, with some limitations due to unspecified participant numbers.
1 citations,
January 2015 in “Journal of Arthritis” Lupus pneumonitis can mimic tuberculosis and should be considered in diagnoses.
15 citations,
April 2011 in “Pediatric Nephrology” New treatments for lupus show promise, but more research is needed, especially for children.