The Rheumatologic Masquerader: A Case Report on SLE-Dermatomyositis-Systemic Scleroderma Overlap Syndrome

August 2023 in “ Rheumatology ”

Mary Kaniu, Deogracia Owende, Angela Migowa

alopecia systemic lupus erythematosus SLE juvenile dermatomyositis systemic scleroderma immunosuppressive therapy intravenous immunoglobulin autoantibodies hair loss lupus IVIG

TLDR Early referral to a pediatric rheumatologist and thorough evaluation are crucial for treating complex overlap syndromes effectively.

This case report describes a 17-year-old African male with an overlap syndrome involving systemic lupus erythematosus (SLE), juvenile dermatomyositis, and systemic scleroderma. Initially diagnosed with SLE, the patient presented with symptoms including muscle weakness, joint pain, alopecia, and skin changes. Laboratory tests revealed elevated inflammatory markers and positive autoantibodies. Management included immunosuppressive therapy, intravenous immunoglobulin, and supportive care, leading to improved functionality and reduced symptoms over three months. The report emphasizes the importance of thorough clinical evaluation and early referral to a pediatric rheumatologist for effective treatment of such complex overlap syndromes.

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