Intermittent and Persistent Type 2 Lupus: Patient Perspectives on Two Distinct Patterns of Type 2 SLE Symptoms

August 2022 in “ Lupus Science & Medicine ”

Amanda M. Eudy, Jennifer L Rogers, Amy Corneli, Kevin McKenna, Mithu Maheswaranathan, David S. Pisetsky, Lisa Criscione‐Schreiber, Jayanth Doss, Rebecca E. Sadun, Kai Sun, Megan E. B. Clowse

Type 2 lupus SLE hair loss rash joint pain

TLDR SLE patients experience two patterns of non-inflammatory symptoms: intermittent and persistent.

Researchers developed a new model to characterize SLE symptoms into Type 1 (inflammatory) and Type 2 (non-inflammatory). Through interviews with 42 SLE patients, they identified two patterns of Type 2 symptoms: Intermittent (n=18) and Persistent (n=24). Intermittent Type 2 symptoms resolve when Type 1 symptoms are inactive, while Persistent Type 2 symptoms continue regardless of Type 1 activity. Persistent Type 2 patients often experience joint pain, hair loss, and rash but less severe organ involvement. This model helps understand the lived experiences of SLE patients.

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