ANA-Negative Lupus Presenting with Segmental Hyalinizing Vasculitis and Valvular Heart Disease – A Rare Case Report

    July 2023
    Widya Inarah Nadhilah Hamid, Femi Syahriani, Faridin Pango, Abdul Rahman Umar, Endy Adnan
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    TLDR Early recognition and aggressive treatment can significantly improve rare ANA-negative lupus with heart and skin issues.
    A 29-year-old woman was diagnosed with ANA-negative Systemic Lupus Erythematosus (SLE) presenting with segmental hyalinizing vasculitis and valvular heart disease. Despite the absence of antinuclear antibodies, her symptoms and clinical findings, including painful skin ulcers, joint pain, fever, and heart issues, met the criteria for SLE. Treatment with hydroxychloroquine, methylprednisolone, and desoximethasone cream led to significant clinical improvement and complete resolution of skin ulcers after 6 months, highlighting the importance of early recognition and aggressive therapy in this rare SLE subset.
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