ANA-Negative Lupus Presenting with Segmental Hyalinizing Vasculitis and Valvular Heart Disease – A Rare Case Report

July 2023

Widya Inarah Nadhilah Hamid, Femi Syahriani, Faridin Pango, Abdul Rahman Umar, Endy Adnan

Systemic Lupus Erythematosus SLE hyalinizing vasculitis valvular heart disease antibodies skin ulcers joint pain fever hydroxychloroquine methylprednisolone desoximethasone cream lupus heart disease Plaquenil Medrol Topicort

TLDR Early recognition and aggressive treatment can significantly improve rare ANA-negative lupus with heart and skin issues.

A 29-year-old woman was diagnosed with ANA-negative Systemic Lupus Erythematosus (SLE) presenting with segmental hyalinizing vasculitis and valvular heart disease. Despite the absence of antinuclear antibodies, her symptoms and clinical findings, including painful skin ulcers, joint pain, fever, and heart issues, met the criteria for SLE. Treatment with hydroxychloroquine, methylprednisolone, and desoximethasone cream led to significant clinical improvement and complete resolution of skin ulcers after 6 months, highlighting the importance of early recognition and aggressive therapy in this rare SLE subset.

View this study on lupus.bmj.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

in Treatment 6 upvotes 4 years ago

Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 243 upvotes 2 months ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 7 months ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

in Chat 15 upvotes 8 months ago

A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

community A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

in Research/Science 6 upvotes 6 months ago

Topical formulations, natural products, and CAM therapies are being used to treat Androgenic alopecia to avoid side effects of Finasteride and Minoxidil. The review covers various low-risk, alternative treatment options.

Similar Research

5 / 1000+ results

research Systemic Lupus Erythematosus (SLE) in the Eastern Region of Saudi Arabia: A Comparative Study

33 citations, August 2013 in “Lupus”

SLE patients in eastern Saudi Arabia have a generally good prognosis despite multi-organ involvement.

research Real-Life Experience with Belimumab in Systemic Lupus Erythematosus: Control of Disease Activity and Flares in a Multicenter Cohort

2 citations, June 2017

Belimumab effectively controls SLE disease activity and reduces steroid use.

research Characteristics of Pregnancy with Systemic Lupus Erythematosus (SLE) in Dr. Mohammad Hoesin Hospital, Palembang

February 2021 in “Indonesian Journal of Perinatology”

Most pregnancies with SLE resulted in intrauterine growth restriction (IUGR).

research Early Symptoms of Systemic Lupus Erythematosus Recalled by 337 SLE Patients

June 2016 in “Annals of the Rheumatic Diseases”

Early symptoms of SLE include fatigue, joint pain, and sensitivity to sunlight.

Chinese SLE Treatment and Research Group Registry XIII: Prevalence and Risk Factors for Chronic Scarring Alopecia in Patients with Systemic Lupus Erythematosus

research Chinese SLE Treatment and Research Group Registry XIII: Prevalence and Risk Factors for Chronic Scarring Alopecia in Patients with Systemic Lupus Erythematosus

1 citations, January 2021 in “Arthritis Research & Therapy”

About 8% of people with systemic lupus erythematosus have chronic scarring alopecia, with certain symptoms and positive antibodies increasing the risk, while immunosuppressants may lower it.