ANA-Negative Lupus Presenting with Segmental Hyalinizing Vasculitis and Valvular Heart Disease – A Rare Case Report
July 2023
A 29-year-old woman was diagnosed with ANA-negative Systemic Lupus Erythematosus (SLE) presenting with segmental hyalinizing vasculitis and valvular heart disease. Despite the absence of antinuclear antibodies, her symptoms and clinical findings, including painful skin ulcers, joint pain, fever, and heart issues, met the criteria for SLE. Treatment with hydroxychloroquine, methylprednisolone, and desoximethasone cream led to significant clinical improvement and complete resolution of skin ulcers after 6 months, highlighting the importance of early recognition and aggressive therapy in this rare SLE subset.
