Chinese SLE Treatment and Research Group Registry XIII: Prevalence and Risk Factors for Chronic Scarring Alopecia in Patients with Systemic Lupus Erythematosus

    January 2021 in “ Arthritis Research & Therapy ”
    Yirong Xiang, Mengtao Li, Hui Luo, Yanhong Wang, Xinwang Duan, Cunyou Zhao, Feng Zhan, Zhenbiao Wu, Hongbin Li, Min Yang, Jian Xu, Wei Wei, Lijun Wu, Hanxiao You, Jianfei Qian, Xiaoxi Yang, Can Huang, Jiuliang Zhao, Qian Wang, Xiaomei Leng, Xin Tian, Yan Zhao, Xiaofeng Zeng
    Image of study
    TLDR About 8% of people with systemic lupus erythematosus have chronic scarring alopecia, with certain symptoms and positive antibodies increasing the risk, while immunosuppressants may lower it.
    In a study involving 4792 patients with systemic lupus erythematosus (SLE) from the Chinese SLE Treatment and Research Group (CSTAR) registry, the prevalence of chronic scarring alopecia was determined to be 7.80%. The research, conducted by Xiang et al., identified mucocutaneous lesions, a high Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR-DI), and positive anti-Smith (anti-Sm) antibodies as risk factors for the development of scarring alopecia. In contrast, the presence of renal and cardio-respiratory involvements and the use of immunosuppressants were found to be negatively associated with the occurrence of scarring alopecia. The study concluded that proactive treatment strategies are crucial in preventing the development of scarring alopecia in patients with SLE.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 215 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

      in Chat  15 upvotes 7 months ago
      A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

    Related Research

    6 / 6 results