Non-Scarring Alopecia of Lupus Erythematosus: A Comprehensive Review

    A. Perales, Dan Lipsker, B. Cribier, C. Lenormand
    This review analyzed data from 237 patients across 27 publications to provide an updated overview of non-scarring alopecia (NSA) in lupus erythematosus (LE) patients. It found that diffuse/patchy NSA and lupus hair are strongly associated with systemic LE activity, show subtle signs of inflammation, and typically respond well to SLE therapy without progressing to scarring alopecia. In contrast, NSA associated with dermal cutaneous LE or lupus panniculitis of the scalp is less commonly linked to SLE and responds better to skin-directed therapies. The study suggests that diffuse/patchy NSA and lupus hair may be variations of a single LE-specific entity and calls for prospective studies to further explore this manifestation.
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