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    Glossary Skin Substitutes

    materials used to replace or repair damaged skin

    Skin substitutes are materials used to replace or aid in the repair of damaged skin, often in cases of severe burns, chronic wounds, or extensive skin loss. These can be made from natural sources like human or animal tissues, or synthetic materials designed to mimic the properties of skin, providing a temporary or permanent solution to promote healing and protect underlying tissues.

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    1. Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and after Transplantation 2008 · 120 citations
    2. Prevascularization of dermal substitutes with adipose tissue-derived microvascular fragments enhances early skin grafting Scientific Reports · 2018 · 57 citations
    3. Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic British Journal of Dermatology · 2017 · 50 citations
    4. The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes Scientific Reports · 2022 · 11 citations
    5. [Employment of current results of tissue engineering in the development of skin substitutes]. PubMed · 2012
    6. Vascularization of skin substitute constructed by vascular endothelial growth factor 165 gene-modified hair follicle stem cells compounded with three-dimensional gelatin-chondroitin sulfate-hyaluronic acid 2014
    7. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013 · 41 citations
    8. Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice Wound Repair and Regeneration · 2012 · 12 citations
    9. Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation Biomedicines · 2021 · 5 citations
    10. De novo hair morphogenesis in engineered skin substitutes OhioLink ETD Center (Ohio Library and Information Network) · 2012 · 1 citations
    11. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells Experimental Dermatology · 2012 · 46 citations
    12. Fabrication of Bio-Based Gelatin Sponge for Potential Use as A Functional Acellular Skin Substitute Polymers · 2020 · 28 citations
    13. Bioengineered skin substitutes: key elements and novel design for biomedical applications International Wound Journal · 2012 · 22 citations
    14. Composite skin substitutes, 3D skin bioprinting and the “BioMask” concept in regenerating skin defects - review Journal of Education Health and Sport · 2024 · 1 citations
    15. 626 Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo Journal of Investigative Dermatology · 2021
    16. Tissue-engineered dermal substitutes constructed by human embryonic stem cell-derived fibroblasts facilitate the repair of skin wounds Frontiers in Bioengineering and Biotechnology · 2026
    17. Effect of Cultured Dermal Substitute Composed of Collagen Sponge Seeded with Fibroblasts in Simultaneous Skin Graft Overlay JOURNAL OF THE KYORIN MEDICAL SOCIETY · 2001 · 1 citations
    18. Optical Behavior of Human Skin Substitutes: Absorbance in the 200–400 nm UV Range Biomedicines · 2022 · 15 citations
    19. Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo Stem cell research & therapy · 2020 · 12 citations
    20. 0873 Modeling junctional epidermolysis bullosa using tissue-engineered skin substitutes Journal of Investigative Dermatology · 2025
    21. Reconstruction of Tissue Engineered Skin Substitute Containing Appendages Using Dermal Papillae Cells And Keratinocytes Journal of Tissue Engineering and Reconstructive Surgery · 2011
    22. Evaluation of Signs of Skin Aging in Patients with Metabolic Syndrome after Substitution Therapy with Antioxidants. Summary of the Doctoral Thesis 2021
    23. Growth hormone substitution in adult growth hormone‐deficient men augments androgen effects on the skin Clinical Endocrinology · 1997 · 55 citations
    24. Development of modified montmorillonite-bacterial cellulose nanocomposites as a novel substitute for burn skin and tissue regeneration Carbohydrate Polymers · 2018 · 93 citations
    25. Dermal Papilla Cells Improve the Wound Healing Process and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells Stem Cells Translational Medicine · 2014 · 68 citations
    26. Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute Stem cell research & therapy · 2014 · 45 citations
    27. Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin Journal of Biological Engineering · 2017 · 105 citations
    28. Epidermal stem cells and skin tissue engineering in hair follicle regeneration World Journal of Stem Cells · 2015 · 83 citations
    29. Advanced therapies of skin injuries Wiener Klinische Wochenschrift · 2015 · 28 citations
    30. Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice PLoS ONE · 2014 · 28 citations