37 citations
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June 2021 in “Journal of the European Academy of Dermatology and Venereology” This review discusses how acute exposures to environmental and internal stressors can quickly alter skin functions, leading to various dermatological symptoms, and calls for more research on these short-term effects.
July 2026 in “Clinical Cosmetic and Investigational Dermatology” In this cross-sectional study of healthy urban women in Shanghai, poor sleep quality and elevated perceived stress were linked to various self-reported dermatological issues and clinical signs, reinforcing the potential relevance of psychological factors in skin health.
March 2026 in “Wiadomości Lekarskie” This narrative review explores how psychological stress may contribute to premature skin aging by affecting dermal collagen and elastin remodeling through neuroendocrine, molecular, and cellular pathways, highlighting potential therapeutic targets to preserve skin structure and function.
5 citations
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September 2022 in “Antioxidants” This study found that the clionasterol-rich hexane fraction of Caulerpa racemosa may protect against particulate matter-induced skin damage by reducing oxidative stress and mitochondrial-mediated apoptosis in human keratinocytes and zebrafish.
1 citations
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July 2022 in “International journal of dermatology and clinical research” This article discusses the complexity of developing treatments for skin diseases due to their multifactorial pathogenesis and reports no new experimental results.
April 2026 in “Inflammopharmacology” This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.
March 2020 in “The Egyptian Journal of Histology” This study found that topical olive oil may protect mice skin from damage caused by electromagnetic radiation, particularly when applied before exposure, by mitigating oxidative, inflammatory, and heat shock stress factors.
286 citations
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June 2012 in “Nature Immunology” In this study, researchers found that mouse hair follicles recruit Langerhans cells by secreting chemokines, acting as key portals for these cells in both mice and humans.
88 citations
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May 2020 in “Clinical therapeutics” This review discusses the role of stress mediators in skin diseases and reports no new clinical results; the authors suggest further research in skin psychoneuroimmunology.
73 citations
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January 2013 in “European journal of dermatology/EJD. European journal of dermatology” This review examines current research on antioxidants in autoimmune skin diseases like alopecia areata and vitiligo, concluding with suggestions for future studies and treatment possibilities without reporting new clinical results.
21 citations
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January 1988 in “Stress Medicine” This review discusses the developmental and psychological significance of skin and emphasizes the need for considering stress effects when evaluating and treating psychocutaneous diseases, without reporting new clinical results.
2 citations
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November 2011 in “InTech eBooks” This article reviews how the skin's peripheral stress response system mirrors the central HPA axis, facilitating local homeostasis under stress, but presents no new findings.
June 2026 in “Reports of Morphology” This study on female Wistar rats with stress-induced alopecia found that a modified diet rich in antioxidants and nutrients reduced dystrophic skin changes and preserved the functional activity of hair follicles, suggesting dietary approaches may support hair restoration under chronic stress conditions.
1 citations
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September 2015 in “Pathology - Research and Practice” Stress during pregnancy can thin fetal skin.
July 2026 in “The Journal of Immunology” This study observed that in both mouse and human models of alopecia areata, T cells exhibit a stress response involving heat shock proteins and other regulatory markers, suggesting their potential as targets for therapeutic intervention in this autoimmune skin disease.
36 citations
,
May 2025 in “Antioxidants” This study found that lipid peroxidation products play a clear role in the pathogenesis of skin diseases like psoriasis, vitiligo, and alopecia, but their role in diseases like melanoma and atopic dermatitis remains unclear.
April 2017 in “Journal of Investigative Dermatology” This study found that down-regulation of sonic hedgehog gene expression is a critical early event in chemotherapy-induced tissue damage in hair and feather follicles.
December 2025 in “Biomedicine & Pharmacotherapy” This study found that Melamax®, originally developed as an eco-friendly hair dye, provides significant protection against ultraviolet-induced oxidative and inflammatory damage in keratinocytes by modulating gene expression and signaling pathways, highlighting its dual potential for cosmetic coloration and skin photoprotection.
November 2025 in “BMC Genomics” This study found that the systemic wrinkled skin phenotype in Xiang pigs involves gene expression changes and genetic variations associated with oxidative stress and extracellular matrix components, resembling features seen in Shar-Pei dogs.
This study suggests that the exercise-induced cytokine IL-15 can improve wound healing in aged skin, along with previously reported benefits on skin structure and mitochondrial function.
375 citations
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July 2006 in “Journal of Investigative Dermatology” This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.
67 citations
,
July 2016 in “Reviews in Endocrine and Metabolic Disorders” This review discusses the complex relationship between stress and various skin conditions, highlighting the role of the skin in the stress response and the brain-skin communication pathways, but reports no new research findings.
November 2023 in “Curēus” This study in Saudi Arabia found that psychological stress was strongly linked to skin symptoms, with conditions like psoriasis, eczema, acne, rash, and baldness showing significant associations, highlighting the importance of considering stress levels when diagnosing skin issues.
215 citations
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March 2018 in “Archives of Toxicology” This study found that PM2.5 exposure induced oxidative stress in human keratinocytes and mouse skin, causing cellular damage, which was mitigated by the antioxidant N-acetyl cysteine.
This thesis found that inhibiting IL-17 and IL-23 improved chronic wound healing in obese, diabetic mice by promoting a pro-healing macrophage phenotype, while ST2 signaling was also necessary for effective wound healing.
September 2004 in “Experimental Dermatology” In this study, neutralizing nerve growth factor reduced stress-triggered hair loss in mice, suggesting that nerve-immune system interactions and neurogenic inflammation contribute to this condition.
September 2026 in “International Journal of Innovative Technologies in Social Science” This review discusses the relationship between physical activity and skin aging, highlighting that regular moderate exercise may benefit skin health but excessive exercise could increase oxidative stress and damage.
September 2020 in “Benha Veterinary Medical Journal” This study found that non-infectious skin conditions in sheep were associated with oxidative stress and changes in trace elements, vitamin A, and immunoglobulin levels.
January 2026 in “Environmental Science and Pollution Research” In this study, oral administration of wheat sprout extract significantly protected rats against skin damage caused by acrylamide exposure by enhancing antioxidant defenses, reducing oxidative stress, and preserving skin structure, highlighting its potential as a sustainable protective agent against environmental skin toxins.
January 2012 in “Zhongguo linchuang xinlixue zazhi” This study found that oxidative stress from chronic restraint stress delayed the anagen phase in the hair cycle of mice, but antioxidant treatment partially reversed this effect.