35 citations
,
May 2021 in “Nature communications” This study found that basement membrane components and structures in mouse hair follicles are highly specialized for specific inter-tissue interactions, with laminin α5 playing a crucial role in hair cycle regulation and anchoring.
31 citations
,
March 2013 in “Gene” This study sequenced and analyzed the goat skin transcriptome, revealing genes involved in signal transduction and cell communication that are differentially expressed during hair growth phases, providing insights for Cashmere goat breeding.
30 citations
,
July 2018 in “Scientific Reports” In this study, a high-fat, high-cholesterol diet in atherosclerotic mice led to skin inflammation and hair problems, which could be reversed by inhibiting glycosphingolipid synthesis.
15 citations
,
February 2015 in “Cell & tissue research/Cell and tissue research” This review examines the role of P-cadherin in skin and hair biology, emphasizing its importance in human hair growth, cycling, and pigmentation, and reports no new research findings.
4 citations
,
January 2019 in “International journal of molecular sciences” This study suggests that β-catenin plays an important role in wool follicle development in transgenic sheep by enhancing the expression of keratin protein genes.
3 citations
,
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study revealed key cellular dynamics and interactions during early embryonic mouse skin development, highlighting complex transitions from precursor states to diverse multilayered structures.
2 citations
,
December 2022 in “Scientific Data” This study used single-cell ATAC sequencing to map chromatin accessibility in developing mouse hair follicles, offering insights into the transcriptional regulation and epigenetic mechanisms underlying hair follicle development.
1 citations
,
July 2016 in “Livestock science” This study suggests that nerve growth factor may support hair follicle growth in Liaoning cashmere goats through pathways involving its receptor, TrkA, particularly during the anagen phase.
This dissertation reported that the loss of Ovol2 impairs hair follicle regeneration and wound repair in mice, highlighting its role in regulating directional migration of epithelial cells.
184 citations
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September 2006 in “PLoS Genetics” This study found that loss of Apc due to K14-cre-mediated gene recombination in mice led to aberrant growth in ectodermally derived squamous epithelia, implicating its critical role in specifying epithelial cell fates during embryonic development.
29 citations
,
July 2014 in “PloS one” In this study, Meis1 was found to regulate epidermal homeostasis and act as a proto-oncogenic factor in skin tissues, with differences in expression patterns between normal and tumor cells.
26 citations
,
January 2014 in “Cell Structure and Function” This study provides evidence that human sweat gland myoepithelial cells contain stem cells capable of self-renewal and differentiating into sweat gland luminal cells.
2 citations
,
August 2020 in “Scientific reports” This study identified genes potentially involved in the development and differentiation of skin appendages in Atelerix albiventris, noting significant enrichment of immune-related genes in hair-type tissues.
2 citations
,
April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reveals that basement membrane composition and structure in mouse hair follicles are specialized for distinct inter-tissue interactions, with laminin α5 being essential for maintaining these interfaces.
May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair-type tissues in hedgehogs show higher enrichment of immune-related genes compared to spine-type tissues, suggesting that spines evolved to protect against injuries and infections.
January 2014 in “Durham e-Theses (Durham University)” In this study, the activation of Notch1 signaling in keratinocytes was found to play a key role in recruiting immune cells and facilitating skin repair after injury.
84 citations
,
October 2014 in “PLoS Genetics” This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.
62 citations
,
November 2009 in “Aging Cell” Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.
1 citations
,
April 2025 in “Pediatria i Medycyna Rodzinna” This research re-analyzed single-cell gene expression data from a mouse model, confirming that certain genes involved in the EDA-EDAR and WNT pathways are crucial for skin appendage development, suggesting that their restoration may mitigate the effects of hypohidrotic ectodermal dysplasia in children.
August 2024 in “Journal of Animal Science and Technology” This study identified specific keratin-associated protein genes that are highly expressed in different varieties and sexes of Angora goats, providing insights for improving mohair development through targeted breeding strategies.
January 2018 in “Stem cell biology and regenerative medicine” This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.
54 citations
,
July 2017 in “Scientific Reports” This study found that the JMJD3/NF-κB-Notch1 pathway plays a crucial role in regulating keratinocyte migration and skin wound healing, with Notch1 affecting key genes involved in cell migration.
April 2017 in “Journal of Investigative Dermatology” This study suggests that dermal Wnt/β-catenin activation timing is crucial for hair follicle initiation, with potential non-cell autonomous regulation of dermal condensate size.
September 2016 in “Journal of dermatological science” This study identified TSC2 as an important regulator of hair follicle morphogenesis and patterning, with Tsc2cKO mice showing altered hair patterns and frequencies compared to controls.
August 2023 in “Journal of Investigative Dermatology” Skin organoids can regenerate hair by forming specific cell units with certain signals.
August 2018 in “Journal of Investigative Dermatology” This study found that humans have a much higher eccrine gland density than chimpanzees and macaques, suggesting a unique evolutionary path for human skin features.
113 citations
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September 2005 in “Journal of Investigative Dermatology” This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.
This study found that Shh and Dhh overexpression in mouse basal cells led to similar epidermal and limb phenotypes, suggesting Dhh functions similarly to Shh in skin, unlike Ihh.
169 citations
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January 2018 in “Cell Reports” In this study, researchers successfully derived skin organoids from mouse pluripotent stem cells that spontaneously produce hair follicles, potentially aiding in hair growth research and in vitro drug testing.
125 citations
,
February 2007 in “The EMBO Journal” Fgfr2b helps maintain healthy skin and prevent cancer.