Newly Born Mesenchymal Cells Disperse Through Rapid Mechanosensitive Migration

    January 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Jon Riddell, Shahzeb Raja Noureen, Luigi Sedda, James D. Glover, William Ho, Connor A. Bain, Arianna Berbeglia, Helen Brown, Calum Anderson, Yuhang Chen, Michael L. Crichton, Christian A. Yates, Richard L. Mort, Denis J. Headon
    Image of study
    TLDR Newly born mesenchymal cells quickly spread out in response to tissue tension during early development.
    This study investigates the dispersal of embryonic mesenchymal cells, which are crucial for the formation of structures such as hair follicles and intestinal villi. Through imaging of mouse and chicken embryonic skin, the researchers discovered that these cells exhibit a rapid migration phase for three hours during early interphase, immediately after cell division. This phase is characterized by high speed and persistence, allowing the cells to travel long distances and join dermal condensates. The direction and velocity of the cells' migration and division are influenced by the mechanical tension within the tissue. The findings highlight the importance of a specific cell cycle sub-phase, early G1, in the dispersal and recruitment of mesenchymal cells to areas where they contribute to key developmental processes.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 13 results

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  301 upvotes 1 year ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

    Similar Research

    6 / 1000+ results