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The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

DNA profiling in forensics has improved, but predicting physical traits and ancestry from DNA has limitations and requires ethical consideration.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Researchers found 19 genes important for root hair growth in a plant called Arabidopsis.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.