January 2006 in “Zhonghua miniao waike zazhi” This study established a stable rabbit model of hypospadias using finasteride, finding varied rates of the condition's severity and associated testicular retention across different gestation day treatments.
11 citations
,
June 2005 in “Postgraduate Medical Journal” This case report details an instance of transient scrotal hair development in a UK infant, which spontaneously resolved by 7 months of age, with no underlying pathology identified.
13 citations
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November 2019 in “Scientific reports” This study found that inhibiting 5α-reductase in molluscs provokes a specific shell morphology, suggesting gastropods might have unique 5α-reductase substrates absent in vertebrates.
21 citations
,
December 2015 in “Development Growth & Differentiation” This study introduces genital sex differentiation parameters (GSDP) to analyze sexual differences in external genitalia and perineum development in mice, revealing varied sensitivity to androgen inhibition in genital structures.
January 2018 in “Elsevier eBooks” This review discusses the role of DHT in male sexual differentiation and fertility in individuals with 5α-reductase-2 deficiency, reporting no new clinical results.
53 citations
,
January 1986 in “Endocrinology” This rat study suggests that 5α-dihydrotestosterone plays a critical role in inhibiting nipple development in male fetuses by causing the regression of the nipple anlage in utero.
October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that a mild intramuscular dose of BOTOX increased spermatogenesis and improved sperm quality in ageing mice, suggesting potential benefits for managing male infertility.
2 citations
,
May 2019 in “PubMed” This study on rats found that finasteride and dutasteride increased collagen density in penile tissues and caused changes in prostate cells, but did not significantly alter erectile pressures compared to controls.
This study found that prenatal exposure to finasteride in rats disrupted male reproductive development, causing physical alterations such as delayed preputial separation and increased nipple retention.
31 citations
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September 2009 in “Natural Product Research” In this study, petroleum ether extract of Citrullus colocynthis fruit effectively promoted hair growth in a mouse model of androgen-induced alopecia, showing comparable results to the standard treatment, finasteride.
February 2026 in “European Urology” April 2022 in “The Journal of Sexual Medicine” This study reports that simultaneous cystoscopy, electroejaculation, transurethral resection of ejaculatory ducts, and seminal vesiculography were safe and effective in diagnosing and treating concurrent hematospermia and anorgasmia.
23 citations
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January 2007 in “Archives of Andrology” This study reported that semen quality improved in three young men after discontinuing long-term finasteride use, although meiotic abnormalities persisted.
44 citations
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June 1967 in “The journal of nutrition/The Journal of nutrition” This study found that essential fatty acid deficiency in rabbits leads to significant degeneration of gonadal tissue, possibly due to impaired anterior pituitary gland function.
This article reviews the role of hormones in human penis development and associated conditions due to hormonal imbalances, but reports no new findings, suggesting hormone replacement can manage some conditions.
25 citations
,
November 2005 in “PubMed” This study found that finasteride altered androgen receptor expression in the rat epididymis without affecting the morphology of epididymal epithelium, suggesting a change in hormonal status.
January 2003 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This review discusses the dermatological impacts of hypogonadism in men, including skin thinning, reduced body hair, and skin reactions to testosterone therapy, but reports no new clinical results.
5 citations
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December 2018 in “Frontiers in Endocrinology” This study found that nuclear androgen receptor expression was enhanced by dihydrotestosterone in rat gubernacular mesenchyme, but this did not affect muscle morphology or matrix composition during fetal development.
46 citations
,
August 2022 in “Journal of Endocrinological Investigation” In this study, the authors concluded that COVID-19 may not cause direct long-term harm to testicular function, but temporary indirect effects could occur, suggesting a possible delay in pursuing parenthood post-recovery.
1 citations
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December 2018 in “Journal of Cosmetic Dermatology” In this study, androgenetic alopecia patients with thin hair were found to have a higher likelihood of experiencing prostatic enlargement and related urinary symptoms compared to those with thicker hair.
18 citations
,
May 2002 in “BJUI” This study found that chronic exposure to finasteride did not significantly impact spermatogenesis in rats.
July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS” This article reviews the potential causes of insufficient androgen action during fetal development, such as enzyme and receptor gene mutations or environmental disruptors, but reports no new results.
January 2018 in “日本薬理学会年会要旨集 =” This study reports that in young male patients with finasteride-associated infertility, semen parameters appear reversible after discontinuing the medication.
1 citations
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January 2010 in “Clinica Veterinaria De Pequenos Animales” In this case report, treatment with antibiotics, finasteride, and prostate omentalization restored fertility in a 6-year-old German Shepherd with prostatitis and astenoteratozoospermia, avoiding surgical castration.
2 citations
,
December 2017 in “Theriogenology” This study found that V-ATPase plays a role in the acidification of vas deferens fluid under the influence of testosterone in orchidectomized rats.
10 citations
,
February 2019 in “Toxicological Sciences” This study reports that chemically induced short anogenital distance in male rat fetuses involved distinctive transcriptional changes, suggesting roles for estrogen and Wnt2 signaling in anogenital tissue development.
June 2026 in “Kocatepe Veterinary Journal” This study found that periodic intratesticular PRP administration may slightly enhance testicular development in male lambs, indicated by increased testicular blood flow, length, and reduced resistance index compared to saline.
September 2017 in “Journal of Investigative Dermatology” This study found that their novel 3D-imaging method, ASAXA-μCT, identified shrinkage of sweat glands as a key factor in skin aging, which leads to dermal defects, decreased elasticity, and increased wrinkling and sagging.
29 citations
,
September 1983 in “British Journal of Dermatology” This study found that men with androgenetic alopecia had significantly lower levels of sex hormone binding globulin and higher salivary testosterone compared to controls, while plasma testosterone levels did not differ.
3 citations
,
February 2018 in “Human Reproduction” This study reports that a young man with severe testotoxicosis maintained spontaneous fertility despite suppressed FSH levels, underscoring the importance of high intratesticular testosterone levels for spermatogenesis.